D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats.

Synapse
Panayotis K ThanosN D Volkow

Abstract

Dopamine (DA) D2 receptor (D2R) agonists and antagonists can modulate self-administration behavior, conditioned place preference, and locomotor responses to cocaine. Low levels of D2R have also been observed in cocaine addicted subjects and in non human primates after chronic cocaine exposures. Prior studies had shown that D2R upregulation in the nucleus accumbens (NAc) in rodents trained to self-administer alcohol markedly attenuated alcohol preference and intake. Here we assess the effects of D2R upregulation in the NAc on cocaine intake in rats trained to self-administer cocaine. Following 2 weeks of i.v. cocaine self-administration (CSA), rats were stereotaxically treated with an adenovirus that carried the D2R gene to upregulate D2R in the NAc. D2R vector treatment resulted in a significant decrease (75%) in cocaine infusions and lever presses (70%) for cocaine. This effect lasted 6 days before cocaine consumption returned to baseline levels, which corresponds roughly to the time it takes D2R to return to baseline levels. These findings show that CSA and D2R in the NAc are negatively correlated and suggest that cocaine intake is modulated in part by D2R levels in NAc. Thus strategies aimed at increasing D2R expression in N...Continue Reading

References

Feb 1, 1992·Journal of Neurochemistry·V Adam-Vizi
Jun 28, 1992·Annals of the New York Academy of Sciences·G Di ChiaraE Carboni
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·W A Corrigall, K M Coen
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Oct 1, 1993·Trends in Neurosciences·G Levi, M Raiteri
Dec 28, 1995·Brain Research. Molecular Brain Research·H IkariG S Roth
Jan 1, 1996·Journal of Addictive Diseases·N D VolkowG J Wang
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·I SoraG R Uhl
Feb 10, 1999·Experimental Gerontology·D K IngramG S Roth
Dec 6, 2000·Psychopharmacology·F O RisingerD K Grandy
Sep 13, 2001·Journal of Neurochemistry·P K ThanosR Hitzemann
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ernest P Noble
May 29, 2004·Alcoholism, Clinical and Experimental Research·Panayotis K ThanosNora D Volkow
Jul 1, 2006·Critical Reviews in Neurobiology·Jeffery D Steketee
Jun 30, 2007·Pharmacology, Biochemistry, and Behavior·Panayotis K ThanosNora D Volkow

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Citations

Aug 14, 2012·Journal of Psychoactive Drugs·Kenneth BlumDebmalya Barh
Aug 5, 2009·Addiction Biology·Cleo L CrunelleJan Booij
Oct 4, 2011·Annual Review of Pharmacology and Toxicology·Nora D VolkowDardo Tomasi
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alice DobiVeronica A Alvarez
Mar 4, 2014·Nature Neuroscience·Ian MazeEric J Nestler
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kicheon ParkCongwu Du
May 15, 2015·Expert Opinion on Biological Therapy·Kenneth BlumMark S Gold
Feb 7, 2016·Neuroscience and Biobehavioral Reviews·Robert M KesslerMarc N Potenza
Apr 10, 2013·Neuroscience and Biobehavioral Reviews·Daniel KofinkMartien J Kas
Feb 22, 2012·Neuroscience and Biobehavioral Reviews·Kanwar VirdeeJeffrey W Dalley
Aug 9, 2011·Biological Psychiatry·Jennifer A DiNieriYasmin L Hurd
Oct 9, 2009·Biological Psychiatry·Diana MartinezHerbert D Kleber
Aug 12, 2009·Brain Research Bulletin·H SershenA Lajtha
Sep 29, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N D VolkowR D Baler
Dec 8, 2011·Depression and Anxiety·Stephanie M Groman, J David Jentsch
May 18, 2011·Synapse·Panayotis K ThanosNora D Volkow
Aug 24, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nora D VolkowRuben Baler
Feb 2, 2010·Physiology & Behavior·Hideo SuzukiLouis R Lucas
May 12, 2015·Neuroscience and Biobehavioral Reviews·Alejandro Higuera-MatasEmilio Ambrosio
Mar 4, 2015·ACS Chemical Neuroscience·Nora D VolkowRuben Baler
Apr 16, 2015·Nature Reviews. Neuroscience·David J NuttPaul R A Stokes
Feb 5, 2013·Biological Psychiatry·Nora D VolkowRuben D Baler
Oct 4, 2014·Frontiers in Psychology·Kenneth BlumMark S Gold
Oct 26, 2016·Neurotoxicity Research·Verónica PastorMaría Eugenia Pallarés
Dec 6, 2017·International Review of Psychiatry·Adam J Stark, Daniel O Claassen
Apr 4, 2018·Medicine and Science in Sports and Exercise·Lisa S RobisonPanayotis K Thanos
Mar 17, 2017·Annual Review of Clinical Psychology·David H Zald, Michael T Treadway
Mar 1, 2010·Expert Review of Endocrinology & Metabolism·Julia P Dunn, Naji N Abumrad
Sep 12, 2019·Physiological Reviews·Nora D VolkowRuben Baler
Feb 23, 2020·Frontiers in Behavioral Neuroscience·Cristina E María-Ríos, Jonathan D Morrow
Apr 20, 2017·Frontiers in Psychiatry·Peter de HaanBert A 't Hart
Dec 7, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lauren K DobbsVeronica A Alvarez

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