D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Rebecca L ClarksonKevin J Bender

Abstract

The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, is expressed throughout limbic circuits affected in neuropsychiatric disorders, including prefrontal cortex (PFC). These receptors are important for prefrontal executive function because pharmacological and genetic manipulations that affect prefrontal D3 receptors alter anxiety, social interaction, and reversal learning. However, the mechanisms by which D3 receptors regulate prefrontal circuits and whether D3 receptors regulate specific prefrontal subnetworks remains unknown. Here, we combine dopamine receptor reporter lines, anatomical tracing techniques, and electrophysiology to show that D3 receptor expression defines a novel subclass of layer 5 glutamatergic pyramidal cell in mouse PFC (either sex). D3-receptor-expressing pyramidal neurons are electrophysiologically and anatomically separable from neighboring neurons expressing D1 or D2 receptors based on their dendritic morphology and subthreshold and suprathreshold intrinsic excitability. D3-receptor-expressing neurons send axonal projections to intratelencephalic (IT) targets, including contralateral cortex, nucleus accumbens, and basolateral amygdala. Within these neurons, D3 receptor ...Continue Reading

Citations

Nov 14, 2019·British Journal of Pharmacology·Maria A MeierZoltan Gerevich
Feb 29, 2020·Neuropsychiatric Disease and Treatment·Christoph U Correll, Nina R Schooler
Oct 20, 2017·Frontiers in Pharmacology·Sebastiano Alfio TorrisiGian Marco Leggio
May 10, 2019·Frontiers in Cellular Neuroscience·Wei ZhangJuan José Garrido
Aug 9, 2020·Frontiers in Pharmacology·Jean Claude Martel, Silvia Gatti McArthur
Jun 4, 2019·Frontiers in Cellular Neuroscience·Kenneth J Burke, Kevin J Bender
Jun 20, 2020·ELife·Naomi Ak HanemaaijerMaarten Hp Kole
Apr 4, 2021·Biomedicines·Kathryn Lanza, Christopher Bishop
Jun 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Glenn DalléracJean-Pierre Mothet

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