Abstract
The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, is expressed throughout limbic circuits affected in neuropsychiatric disorders, including prefrontal cortex (PFC). These receptors are important for prefrontal executive function because pharmacological and genetic manipulations that affect prefrontal D3 receptors alter anxiety, social interaction, and reversal learning. However, the mechanisms by which D3 receptors regulate prefrontal circuits and whether D3 receptors regulate specific prefrontal subnetworks remains unknown. Here, we combine dopamine receptor reporter lines, anatomical tracing techniques, and electrophysiology to show that D3 receptor expression defines a novel subclass of layer 5 glutamatergic pyramidal cell in mouse PFC (either sex). D3-receptor-expressing pyramidal neurons are electrophysiologically and anatomically separable from neighboring neurons expressing D1 or D2 receptors based on their dendritic morphology and subthreshold and suprathreshold intrinsic excitability. D3-receptor-expressing neurons send axonal projections to intratelencephalic (IT) targets, including contralateral cortex, nucleus accumbens, and basolateral amygdala. Within these neurons, D3 receptor ...Continue Reading
Citations
Feb 7, 2020·Cerebral Cortex·Danqing YangDirk Feldmeyer
Nov 14, 2019·British Journal of Pharmacology·Maria A MeierZoltan Gerevich
Feb 29, 2020·Neuropsychiatric Disease and Treatment·Christoph U Correll, Nina R Schooler
Sep 8, 2019·Molecular Psychiatry·G M LeggioF Papaleo
Oct 20, 2017·Frontiers in Pharmacology·Sebastiano Alfio TorrisiGian Marco Leggio
May 10, 2019·Frontiers in Cellular Neuroscience·Wei ZhangJuan José Garrido
Aug 9, 2020·Frontiers in Pharmacology·Jean Claude Martel, Silvia Gatti McArthur
Jun 4, 2019·Frontiers in Cellular Neuroscience·Kenneth J Burke, Kevin J Bender
Jan 16, 2019·Nature Communications·Brendan D HareRonald S Duman
May 28, 2019·Scientific Reports·Elisa GumaBruno Giros
Jun 20, 2020·ELife·Naomi Ak HanemaaijerMaarten Hp Kole
Dec 20, 2018·Cerebral Cortex·Paul G AnastasiadesAdam G Carter
Nov 4, 2020·Experimental Neurology·Jay S SchneiderSandhya Kortagere
Jan 13, 2021·Alcoholism, Clinical and Experimental Research·Max E JoffeP Jeffrey Conn
Jan 22, 2021·Pharmacology & Therapeutics·Danko JeremicJuan D Navarro-Lopez
Jan 21, 2021·Biomolecules·Béla KissViktor Román
Nov 11, 2020·Pharmaceuticals·Sebastiano Alfio TorrisiGian Marco Leggio
Apr 4, 2021·Biomedicines·Kathryn Lanza, Christopher Bishop
Dec 7, 2018·Experimental Neurology·Ibrahim M ShokryRui Tao
Apr 16, 2021·Phytotherapy Research : PTR·Yan-Yan GuoMing-Gao Zhao
May 6, 2021·Cell Reports·Won Chan OhHyung-Bae Kwon
Jun 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Glenn DalléracJean-Pierre Mothet
Jul 3, 2021·Biomedicines·Allen P F ChenQiaojie Xiong
Jul 16, 2021·Psychopharmacology·Viktor RománBéla Kiss
Aug 5, 2021·Cell Reports·Jingliang ZhangYang Yang
Aug 5, 2021·Cell Reports·Perry W E SprattKevin J Bender