D5 receptor agonist 027075 promotes cognitive function recovery and neurogenesis in a Aβ1-42-induced mouse model

Neuropharmacology
Ling ShenLing He

Abstract

In this study, a high throughput screening system was set up to identify D5 receptor agonists-027075. Then, a series of behavior tests were used to evaluate the beneficial effects of 027075 in Aβ1-42-induced mice model including morris water maze, passive avoidance, active avoidance, open field and step-down test. The neuroprotective effect of 027075 was assessed by a high content screening in vitro. In behavior tests, the cognitive function impairment caused by Aβ1-42 was significantly ameliorated by 027075 in a dose-dependent manner. 027075 (8 mg/kg) significantly prolonged the time spent in the target quadrant when compared to the model group in morris water maze test. The latency was significantly increased and the number of errors was decreased in both passives avoidance task and step down test when compared to the model group. In active avoidance and open field test, latency, stimulation time, number of errors were significantly reduced, while number of avoidance and line crossing and central distance were increased by 027075 (8 mg/kg). All the results above was significantly reversed by 027075-H + SCH39166 (5 mg/kg) when compared to 027075-H (8 mg/kg). The neuroprotective effect of 027075 was demonstrated by promotion of...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Mar 28, 1994·Neuroscience Letters·A NittaT Nabeshima
Nov 1, 1995·Brain Research. Brain Research Reviews·A Blokland
May 15, 1998·Neuron·B Pettmann, C E Henderson
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P LambertW L Klein
Nov 26, 1998·The Journal of Biological Chemistry·W Q QiuD J Selkoe
Aug 6, 2004·Nature·Mark P Mattson
Jul 26, 2005·Neuroscience Letters·Antimo D'AnielloPatrizia Spinelli
Jul 11, 2006·European Journal of Pharmacology·Dong Hyun KimJong Hoon Ryu
Aug 1, 2006·Lancet·Kaj BlennowHenrik Zetterberg
Oct 5, 2006·Current Alzheimer Research·Xiongwei ZhuMark A Smith
Apr 17, 2007·Biochimica Et Biophysica Acta·Danielle G SmithKevin J Barnham
Feb 1, 2008·The Journal of Biological Chemistry·Margaret H MagdesianSérgio T Ferreira
Jun 19, 2008·Brain : a Journal of Neurology·Gonzalo I CancinoAlejandra R Alvarez
Aug 13, 2008·Cellular and Molecular Life Sciences : CMLS·J H Stockley, C O'Neill
Dec 5, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanessa VillardTangui Maurice
Jun 30, 2009·Seminars in Cell & Developmental Biology·Jeffrey W Dalley, Barry J Everitt
Dec 1, 2010·The Journal of Biological Chemistry·Sofia JürgensenSergio T Ferreira
Jun 28, 2011·Neurobiology of Aging·Sergey KalininDouglas L Feinstein
Nov 22, 2011·Analytical Chemistry·Eija MartikkalaHarri Härmä
Oct 12, 2013·Neurobiology of Aging·Daniela PuzzoAgostino Palmeri

❮ Previous
Next ❯

Citations

Dec 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ting GuNian-Guang Li
Apr 10, 2019·Current Alzheimer Research·Eunice D Farfán-GarcíaMarvin A Soriano-Ursúa
Oct 18, 2019·International Immunopharmacology·Qing-Peng XiaLing He

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.