Da-Huang-Fu-Zi-Tang Ameliorates Severe Acute Pancreatitis by Elevation of M2 Kupffer Cells in Rats.

Evidence-based Complementary and Alternative Medicine : ECAM
Yi SongXiao-Guang Lu

Abstract

Severe acute pancreatitis (SAP) is a clinical emergency often accompanied by inflammatory response syndrome (SIRS), which eventually leads to acute lung injury and failure of other organs. The activation of liver Kupffer cells (KCs) plays a major role in the process of SIRS and multiorgan damage caused by SAP. Da-Huang-Fu-Zi-Tang (DHFZT), a traditional Chinese prescription, has been widely used for SAP in the clinic. The present study investigated the activation state of KCs in SAP and the potential mechanism of DHFZT. A total of 24 Sprague Dawley rats were randomly assigned to four groups: SH (sham operation group + saline enema), SH-DHFZT (sham operation group + DHFZT enema), SAP (model group + saline enema), and SAP-DHFZT (model group + DHFZT enema). Blood samples were drawn from the abdominal aorta for measuring serum endotoxin, amylase, calcium ion, IL-1β, TNF-α, iNOS, and IL-10. Then, the pancreas, lung, liver, and ileum were harvested for histological observation, and the liver was used to detect the level of F4/80, CD86, and CD163 in KCs with immunohistochemistry and western blot. In the SAP group, the CD86+ KCs were significantly increased with a high level of IL-1β, TNF-α, and iNOS, and the organs were impaired. In th...Continue Reading

References

Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L SuS C Wang
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Feb 21, 2006·World Journal of Gastroenterology : WJG·Hong-Bin LiuChang Chen
Mar 15, 2006·World Journal of Gastroenterology : WJG·Catherine M PastorJean-Louis Frossard
Jun 14, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yanhua PengMichel M Murr
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekihiro Seki, David A Brenner
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucinda J ThompsonStanley Falkow
Nov 12, 2010·International Journal of Molecular Medicine·Sang-Wan SeoSung-Joo Park
Feb 15, 2012·Journal of Gastroenterology and Hepatology·Julia MayerleMarkus M Lerch
Jun 6, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Makiko KobayashiFujio Suzuki
Jan 17, 2014·The Journal of Clinical Investigation·Nuray GülMarjolein van Egmond
May 7, 2014·Journal of Hepatology·Arjan BoltjesAndrea M Woltman
Jun 13, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Rishikesh M KulkarniSusan E Waltz
Nov 24, 2016·International Journal of Molecular Medicine·Jie XiongXingpeng Wang
Jan 14, 2017·Microbiology Spectrum·Takashi Satoh, Shizuo Akira
Mar 18, 2017·Molecular Immunology·Peizhi LiJianping Gong

❮ Previous
Next ❯

Software Mentioned

ISCapture
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.