DAB1: a degenerate retrotransposon-like element from Neurospora crassa

Molecular & General Genetics : MGG
M BibbinsI F Connerton

Abstract

A repeated DNA sequence in the genome of Neurospora crassa has been identified as a family of degenerate retroelements. Retroelements encode protein sequences with clear homology to the reverse transcriptase, RNase H and endonuclease products of the pol genes common to retroviruses and retrotransposons. These sequence comparisons place the N. crassa element within the gypsy group of retrotransposons, akin to other elements found in filamentous fungi. However, the Neurospora element is defective, as no flanking long terminal repeats (LTRs) could be distinguished and the pol gene homologues contain numerous stop codons as a result of multiple base substitutions. The base composition of the element displays significant under-representation of the dinucleotide CpA, the preferred target site of repeat-induced point mutation (RIP). The genomic sequences exhibit G:C to A:T transitions between copies which are diagnostic of RIP. The degenerate retroelement has accordingly been designated by the acronym dab-1 (dead and buried).

Citations

Mar 29, 2001·Fungal Genetics and Biology : FG & B·D D Perkins, R H Davis
Nov 1, 2007·Current Genetics·Claudia RiccioniSergio Arcioni
Dec 4, 2003·Fungal Genetics and Biology : FG & B·J P RamussenD E A Catcheside
May 18, 2012·Molecular Biology and Evolution·Anastasia GiotiHanna Johannesson
Mar 26, 2003·Nucleic Acids Research·Gertrud MannhauptUlrich Schulte
Mar 29, 2002·Molecular Biology and Evolution·Marie-Josée DaboussiThierry Langin
Oct 7, 2003·Annual Review of Microbiology·Marie-Josée Daboussi, Pierre Capy
Apr 25, 2003·Nature·Eric U SelkerMichael Freitag

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