Dabigatran dual therapy with ticagrelor or clopidogrel after percutaneous coronary intervention in atrial fibrillation patients with or without acute coronary syndrome: a subgroup analysis from the RE-DUAL PCI trial

European Heart Journal
Jonas OldgrenChristopher P Cannon

Abstract

After percutaneous coronary intervention (PCI) in patients with atrial fibrillation, safety and efficacy with dabigatran dual therapy were evaluated in pre-specified subgroups of patients undergoing PCI due to acute coronary syndrome (ACS) or elective PCI, and those receiving ticagrelor or clopidogrel treatment. In the RE-DUAL PCI trial, 2725 patients were randomized to dabigatran 110 mg or 150 mg with P2Y12 inhibitor, or warfarin with P2Y12 inhibitor and aspirin. Mean follow-up was 14 months, 50.5% had ACS, and 12% received ticagrelor. The risk of the primary endpoint, major or clinically relevant non-major bleeding event, was reduced with both dabigatran dual therapies vs. warfarin triple therapy in patients with ACS [hazard ratio (95% confidence interval), 0.47 (0.35-0.63) for 110 mg and 0.67 (0.50-0.90) for 150 mg]; elective PCI [0.57 (0.43-0.76) for 110 mg and 0.76 (0.56-1.03) for 150 mg]; receiving ticagrelor [0.46 (0.28-0.76) for 110 mg and 0.59 (0.34-1.04) for 150 mg]; or clopidogrel [0.51 (0.41-0.64) for 110 mg and 0.73 (0.58-0.91) for 150 mg], all interaction P-values >0.10. Overall, dabigatran dual therapy was comparable to warfarin triple therapy for the composite endpoint of death, myocardial infarction, stroke, sy...Continue Reading

References

Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Apr 10, 2007·Journal of the American College of Cardiology·Dominick J AngiolilloMarco A Costa
Dec 9, 2008·American Heart Journal·Shinya GotoUNKNOWN REACH Registry Investigators
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Jan 24, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Thomas PilgrimStephan Windecker
Jun 12, 2013·Journal of the American College of Cardiology·Morten LambertsMorten Lock Hansen
Aug 29, 2013·Stroke; a Journal of Cerebral Circulation·Staffan BjörckLennart Bergfeldt
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Dec 14, 2016·The New England Journal of Medicine·C Michael GibsonKeith A Fox
Aug 29, 2017·The New England Journal of Medicine·Christopher P CannonUNKNOWN RE-DUAL PCI Steering Committee and Investigators
Oct 28, 2017·Journal of the American College of Cardiology·Robert W YehUNKNOWN DAPT Study Investigators
Nov 11, 2017·European Heart Journal. Cardiovascular Pharmacotherapy·Gorav BatraJonas Oldgren
Nov 8, 2018·European Heart Journal·Franz-Josef Neumann, Miguel Sousa-Uva
Dec 20, 2018·Kardiologia polska·Franz Josef NeumannMichael O Zembala

❮ Previous
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Citations

Apr 9, 2019·European Heart Journal·Roxana MehranDominick J Angiolillo
Dec 10, 2019·Therapeutic Advances in Cardiovascular Disease·Sergio BuccheriDavide Capodanno
Jan 17, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mattia GalliFilippo Crea
Sep 23, 2020·Future Cardiology·Krithika LoganathAlastair J Moss
Jun 15, 2019·European Heart Journal. Cardiovascular Pharmacotherapy·Paul M HallerThomas Gremmel
Jul 8, 2020·Journal of Clinical Medicine·Bastiaan ZwartRobert F Storey
Jan 24, 2020·Cardiovascular Intervention and Therapeutics·Antonio MangieriAntonio Colombo
Mar 15, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Despoina-Rafailia BenetouDimitrios Alexopoulos
Oct 12, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Tatjana S PotparaGregory Y H Lip
Jul 10, 2019·Cardiovascular Intervention and Therapeutics·Yuichi Saito, Yoshio Kobayashi
Jul 2, 2020·Journal of Clinical Medicine·Wilbert Bor, Diana A Gorog
Nov 13, 2020·Expert Opinion on Drug Safety·Mattia GalliDominick J Angiolillo
Nov 29, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Andrea Rubboli, Jean-Philippe Collet
Mar 12, 2021·Expert Review of Cardiovascular Therapy·Felix VollSalvatore Cassese
Mar 13, 2021·The American Journal of Cardiology·Christopher P Cannon
Apr 8, 2021·JACC. Cardiovascular Interventions·Benjamin E PetersonUNKNOWN RE-DUAL PCI Steering Committee and Investigators
Apr 26, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan SteffelUNKNOWN External reviewers
Mar 17, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato NakamuraAtsushi Hirayama
Aug 21, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Dominick J Angiolillo, Mattia Galli
Oct 9, 2021·European Heart Journal·Thomas F LüscherStavros V Konstantinides

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