Sep 3, 2010

Dabigatran inhibits Staphylococcus aureus coagulase activity

Journal of Clinical Microbiology
T VanasscheP Verhamme

Abstract

The ability of Staphylococcus aureus to clot plasma through conformational activation of prothrombin by staphylocoagulase is used to distinguish S. aureus from coagulase-negative staphylococci. We show that while the direct thrombin inhibitor dabigatran inhibits staphylocoagulase activity, the clinical use of dabigatran etexilate is not expected to interfere with direct tube coagulase testing.

Mentioned in this Paper

Staphylocoagulase
Clotting Factor II Assay
F2 gene
Dabigatran
Staphylococcus aureus strain 213 of Coagulase
Blood Clot
Staphylococcus aureus
Benzimidazoles
Enzyme Inhibitors
Direct Thrombin Inhibitor [EPC]

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