Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy

Case Reports in Nephrology
Rachele EscoliFernanda Carvalho

Abstract

Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms.

References

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Jul 7, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sergey V BrodskyTibor Nadasdy
Aug 17, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Catalina Martín ClearyJesús Egido
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Sep 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Margaret RyanSergey V Brodsky
Oct 1, 2013·Clinical Kidney Journal·Gilbert W MoeckelUrsula C Brewster

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Citations

Aug 30, 2017·BMJ Case Reports·Basma AbdulhadiJanani Rangaswami
May 8, 2019·International Journal of Molecular Sciences·Juan Antonio MorenoJesús Egido
Dec 30, 2017·Kidney Research and Clinical Practice·Sergey V BrodskyTibor Nadasdy
Jul 18, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Angel M SevillanoUNKNOWN Spanish Group for the Study of Glomerular Diseases (GLOSEN)
Jul 11, 2020·Journal of Clinical Medicine·Raquel EsterasJuan Antonio Moreno
Jun 23, 2020·Case Reports in Nephrology·Letizia ZeniGiovanni Cancarini
Nov 14, 2018·Journal of the American Society of Nephrology : JASN·Sergey BrodskyLee A Hebert
Mar 7, 2021·Journal of Clinical Medicine·Tanja Belčič MikičŽeljka Večerić-Haler

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Methods Mentioned

BETA
biopsy

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