Dabigatran versus warfarin after mechanical mitral valve replacement in the swine model

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
John L SchomburgRichard W Bianco

Abstract

Mechanical heart valve replacement is an absolute indication for anticoagulation. We report our experience comparing dabigatran to warfarin as thromboembolic prophylaxis after mechanical mitral valve replacement in the swine model. Nineteen swine underwent mitral valve replacement with a regulatory approved, 27 mm mechanical valve. Two control groups consisted of three animals receiving no anticoagulation and five animals receiving warfarin (5 mg once a day [QD], adjusted to maintain international normalized ratio [INR] from 2.0 to 2.5). The experimental group consisted of 11 animals receiving dabigatran (20 mg/kg twice a day [BID]). The study period was 90 days. The primary outcome was animal mortality; secondary outcomes included presence of thrombus and bleeding complications. The experimental group had four full-term survivors (40.0%); there were no full-term survivors in either control group. The average length of survival was 50.3 days in the experimental group compared with 18.7 and 15.6 days for the no anticoagulation and warfarin groups, respectively (p = .017). Valve thrombus was observed in all study groups. Hemorrhagic complications were present in 40% of the warfarin group and 27% of the dabigatran group. There was...Continue Reading

References

Aug 1, 1986·The Journal of Surgical Research·R W BiancoJ E Foker
Mar 1, 1993·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E IrwinR Bianco
Sep 30, 1999·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·E U DexterW E Richenbacher
Feb 1, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Manabu SatoAndre S Lee
Sep 30, 2004·The Heart Surgery Forum·Morten SmerupJ Michael Hasenkam
Jun 14, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Liang MaLudwig K von Segesser
Jul 20, 2007·ANZ Journal of Surgery·Demin LiHua Jing
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Apr 7, 2010·Circulation·John W Eikelboom, Jeffrey I Weitz
Jun 1, 2010·Journal of the American College of Cardiology·Shahbudin H Rahimtoola

❮ Previous
Next ❯

Citations

Sep 3, 2013·The New England Journal of Medicine·John W EikelboomUNKNOWN RE-ALIGN Investigators
Oct 4, 2013·BMC Veterinary Research·Annika WeigandJustus P Beier
Dec 19, 2013·Future Cardiology·Farnoosh ZoughRamdas G Pai
Aug 10, 2016·American Heart Journal·Raphaël P MartinsPhilippe Mabo
Aug 31, 2014·Current Atherosclerosis Reports·Peter Forsberg, Maria T DeSancho
Jun 25, 2014·Hospital Pharmacy·Patricia A Howard
Jan 28, 2018·Journal of the American Heart Association·Konstantinos N Aronis, Elaine M Hylek
Aug 5, 2015·American Journal of Therapeutics·Michael LevineStephen H Thomas
Sep 18, 2020·Journal of Cardiac Surgery·Joel AikinsAmer Harky
Aug 25, 2020·Anesthesia and Analgesia·Sergiy M NadtochiyMichael P Eaton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

The Journal of Thoracic and Cardiovascular Surgery
Stephen H McKellarHartzell V Schaff
The New England Journal of Medicine
Stuart J ConnollyRandomized Evaluation of Long-Term Anticoagulation Therapy Investigators
The New England Journal of Medicine
Mary Ross SouthworthEllis F Unger
JAAPA : Official Journal of the American Academy of Physician Assistants
Larissa DeDea
© 2021 Meta ULC. All rights reserved