Daclatasvir + asunaprevir versus sofosbuvir/ledipasvir for hepatitis C genotype 1 in Japanese patients: an indirect comparison

Journal of Comparative Effectiveness Research
Elyse SwallowFiona McPhee

Abstract

To compare daclatasvir + asunaprevir (DCV + ASV) versus sofosbuvir/ledipasvir (SOF/LDV) for hepatitis C virus genotype 1b in Japanese patients without NS5A polymorphisms at L31 and Y93H. All Phase III trials of SOF/LDV and DCV + ASV conducted in Japan were included. To adjust for cross-trial differences, DCV + ASV patients were weighted to match reported SOF/LDV summary baseline characteristics. After adjustment, the rate of SVR12 (99.3 vs 100%; p = 0.398) and discontinuation due to adverse events (1.3 vs 0.0%; p = 0.327) were similar between patients treated with DCV + ASV (n = 252) and SOF/LDV (n = 171). After adjusting for cross-trial differences in baseline characteristics, DCV + ASV and SOF/LDV were associated with similar efficacy and discontinuation due to adverse events in the treatment of hepatitis C virus genotype 1b in Japanese patients without NS5A polymorphisms.

References

Mar 5, 2003·Journal of Viral Hepatitis·F ToccaceliUNKNOWN Italian Hepanet Group
Sep 19, 2007·Journal of Medical Case Reports·Vincenzo CitroGiovanni Tarantino
Jan 14, 2010·Intervirology·Hobyung ChungMasatoshi Kudo
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brian L Pearlman, Nomi Traub
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·William SievertFrancesco Negro
Jan 20, 2012·The New England Journal of Medicine·Anna S LokClaudio Pasquinelli
Nov 20, 2012·BMC Gastroenterology·Adriano M PellicelliUNKNOWN CLEO Group
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Adriaan J van der MeerHarry L A Janssen
Oct 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donald B SmithPeter Simmonds
Mar 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiromitsu KumadaEric Hughes
Apr 12, 2014·The New England Journal of Medicine·Kris V KowdleyUNKNOWN ION-3 Investigators
Jun 13, 2014·Therapeutics and Clinical Risk Management·Tatsuo KandaOsamu Yokosuka
Jul 7, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiromitsu KumadaRebecca Redman

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