dAcquisition setting optimization and quantitative imaging for 124I studies with the Inveon microPET-CT system.

EJNMMI Research
Nadège AnizanManuel Bardiès

Abstract

Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate activity quantification. The decay scheme of 124I implies an optimization of both acquisition settings and correction processing. The PET scanner investigated in this study was the Inveon PET/CT system dedicated to small animal imaging. The noise equivalent count rate [NECR], the scatter fraction [SF], and the gamma-prompt fraction [GF] were used to determine the best acquisition parameters for mouse- and rat-sized phantoms filled with 124I. An image-quality phantom as specified by the National Electrical Manufacturers Association NU 4-2008 protocol was acquired and reconstructed with two-dimensional filtered back projection, 2D ordered-subset expectation maximization [2DOSEM], and 3DOSEM with maximum a posteriori [3DOSEM/MAP] algorithms, with and without attenuation correction, scatter correction, and gamma-prompt correction (weighted uniform distribution subtraction). Optimal energy windows were established for the rat ph...Continue Reading

References

Sep 29, 2000·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·K S PentlowJ L Humm
May 8, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·H HerzogH H Coenen
Nov 1, 2002·Physics in Medicine and Biology·Mark LubberinkHans Lundqvist
Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Stéphan WalrandStanislas Pauwels
Feb 16, 2006·Nuclear Medicine Communications·Stefaan Vandenberghe
Jan 1, 1995·IEEE Transactions on Medical Imaging·C C MartinR J Nickles
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Mar 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jonathan A DisselhorstEric P Visser

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Citations

Jul 14, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas AideRodney J Hicks
Oct 25, 2016·Nuclear Medicine Communications·Sitah F AlanaziSalem A Sassi

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Software Mentioned

2DOSEM
IAW
FORE
Inveon
Inveon Acquisition Workplace
MAP
ASIPro
3DOSEM
ImageJ

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