DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest

Current Biology : CB
L Ryan Baugh, Paul W Sternberg

Abstract

Development is typically studied as a continuous process under laboratory conditions, but wild animals often develop in variable and stressful environments. C. elegans larvae hatch in a developmentally arrested state (L1 arrest) and initiate post-embryonic development only in the presence of food (E. coli in lab). In contrast to the well-studied dauer arrest, L1 arrest occurs without morphological modification, although larvae in L1 arrest are more resistant to environmental stress than developing larvae . Consistent with its role in dauer formation and aging, we show that insulin/insulin-like growth factor (IGF) signaling regulates L1 arrest. daf-2 insulin/IGF receptor mutants have a constitutive-L1-arrest phenotype when fed and extended survival of L1 arrest when starved. Conversely, daf-16/FOXO mutants have a defective-arrest phenotype, failing to arrest development and dying rapidly when starved. We show that DAF-16 is required for transcription of the cyclin-dependent kinase inhibitor cki-1 in stem cells in response to starvation, accounting for the failure of daf-16/FOXO mutants to arrest cell division during L1 arrest. Other developmental events such as cell migration, cell fusion, and expression of the microRNA lin-4, a...Continue Reading

References

Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Nov 1, 1984·Mechanisms of Ageing and Development·T E JohnsonJ Foy
Apr 23, 1981·Nature·D L RiddleP S Albert
Dec 2, 1993·Nature·C KenyonR Tabtiang
Dec 12, 2003·Molecular Biology of the Cell·James F Morley, Richard I Morimoto
Oct 22, 2004·American Journal of Physiology. Cell Physiology·S Todd Lamitina, Kevin Strange
Aug 16, 2005·Science·Leesa LaFever, Daniela Drummond-Barbosa
Aug 17, 2005·Genes & Development·Aurelio A TelemanStephen M Cohen
Apr 25, 2006·Current Biology : CB·Masamitsu FukuyamaJoel H Rothman

❮ Previous
Next ❯

Citations

Mar 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rakesh KarmacharyaEdgar A Buttner
Apr 9, 2008·Oncogene·K K HoE W-F Lam
Oct 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiaochang ZhangMin Han
Jul 4, 2009·The Journal of Biological Chemistry·Irene K Guttilla, Bruce A White
Mar 9, 2010·The Journal of Biological Chemistry·Janet C Koon, Terrance J Kubiseski
May 31, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alexander R MendenhallThomas E Johnson
Feb 5, 2010·Nucleic Acids Research·Peter Ruzanov, Donald L Riddle
Aug 19, 2008·Genes & Development·Nicole Fielenbach, Adam Antebi
Jun 9, 2006·Cell Division·Mike Boxem
Dec 6, 2012·Biology Open·Masamitsu FukuyamaToshiaki Katada
May 2, 2009·Disease Models & Mechanisms·Kevin T Jones, Kaveh Ashrafi
Feb 2, 2012·Journal of Cell Science·Thalyana Smith-Vikos, Frank J Slack
Apr 7, 2007·PLoS Genetics·Sean P Curran, Gary Ruvkun
Oct 25, 2008·PLoS Genetics·James J CollinsKerry Kornfeld
Dec 14, 2011·PloS One·Hannah S Seidel, Judith Kimble
Feb 24, 2012·PloS One·Sebastian J HonnenOlaf Bossinger
Sep 13, 2012·PloS One·Inhwan LeeYoung-Jai You
Aug 1, 2014·Proceedings. Biological Sciences·Vahan SerobyanRalf J Sommer
Nov 25, 2014·Nature Cell Biology·Michael M MuellerBjörn Schumacher
Sep 24, 2013·The Quarterly Review of Biology·Thomas FlattStig W Omholt
Sep 15, 2008·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·N J SzewczykM Viso
Feb 22, 2011·Molecular Reproduction and Development·Katherine A Waters, Valerie Reinke
Mar 17, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tamar D ResnickAnn E Rougvie
Feb 9, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jessica N Landis, Coleen T Murphy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.