Abstract
The present study was designed to check the effect of daidzein in the management of diabetic retinopathy. Streptozotocin at dose 55 mg/kg was used for inducing diabetes in rats. After 28 days of diabetic induction, animals were treated with daidzein at dose 25, 50, and 100 mg/kg for the next 28 days. Electroretinography, estimation of plasma glucose, lactate dehydrogenase, aldose reductase, sorbitol dehydrogenase and oxidative stress parameters were performed at the end of the study. Histopathology of retina was carried out at the end of the study. Diabetic control animals showed a significant increase in levels of plasma glucose and plasma lactate dehydrogenase (p < 0.001). Treatment with daidzein at a dose of 50 and 100 mg/kg significantly reduced the elevated level of blood glucose (p < 0.01 and p < 0.01). Whereas, treatment with daidzein at a dose 100 mg/kg significantly reduced the elevated level of lactate dehydrogenase in plasma after 28 days of treatment (p < 0.01). Treatment with daidzein at a dose of 100 mg/kg significantly reduced the level of aldose reductase and sorbitol dehydrogenase (p < 0.01 and p < 0.001 respectively). Electroretinography revealed that daidzein treatment at a dose of 100 mg/kg significantly pre...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1990·Chemico-biological Interactions·F PaolettiD Aldinucci
Jul 1, 1984·Cell Biochemistry and Function·C L Markert
Jan 1, 1984·Current Eye Research·R E AndersonR D Wiegand
Apr 16, 1998·Diabetes Care·L P AielloR Klein
May 23, 2001·American Journal of Hypertension·M E CooperK Jandeleit-Dahm
Feb 28, 2003·Diabetes·Renu A Kowluru
Aug 5, 2003·Diabetologia·S-H ParkS-J Oh
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jun 6, 2006·Experimental Eye Research·Yan CuiPatrick C P Ho
Jul 21, 2007·Experimental Diabetes Research·Renu A Kowluru, Pooi-See Chan
Jan 29, 2008·Experimental Diabetes Research·Mara Lorenzi
Jan 5, 2012·PloS One·João MartinsAntónio F Ambrósio
Feb 1, 2012·Asian Pacific Journal of Tropical Biomedicine·Dk PatelS Hemalatha
Jun 7, 2013·PloS One·Patricia RiveraJuan Suárez
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Małgorzata Nita, Andrzej Grzybowski
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yogesh A Kulkarni, Mayuresh S Garud
Nov 13, 2017·Pharmacological Reports : PR·Mayuresh S Garud, Yogesh A Kulkarni
Jan 15, 2018·Chemico-biological Interactions·Mayuresh Sudamrao Garud, Yogesh Anant Kulkarni
Mar 23, 2018·International Journal of Molecular Sciences·Anne RübsamPatrice E Fort
May 29, 2018·Journal of Ethnopharmacology·Xiaoqin LeiJianwei Dou
Jun 15, 2018·Nutrients·Qiqi ZhangJun He
Mar 6, 2019·BMJ Open·Riccardo CheloniAnna Odone
Mar 8, 2019·Acta Cirúrgica Brasileira·Changxia DongYuanbin Li
Apr 28, 2019·Experimental Eye Research·Asieh NaderiAlireza Lashay
Nov 18, 2019·Diabetes Research and Clinical Practice·R L ThomasD R Owens
Oct 17, 2020·Drug and Chemical Toxicology·Ankit P LaddhaYogesh A Kulkarni