Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production

Nutrients
Chikara IinoShigeyuki Nakaji

Abstract

Equol is a metabolite of isoflavone daidzein and has an affinity to estrogen receptors. Although equol is produced by intestinal bacteria, the association between the status of equol production and the gut microbiota has not been fully investigated. The aim of this study was to compare the intestinal bacteria responsible for equol production in gut microbiota between equol producer and non-producer subjects regarding the intake of daidzein. A total of 1044 adult subjects who participated in a health survey in Hirosaki city were examined. The concentration of equol in urine was measured by high-performance liquid chromatography. The relative abundances of 8 bacterial species responsible for equol production in the gut microbiota was assessed using 16S rRNA amplification. There were 458 subjects identified as equol producers. The proportion of equol production status and the intake of daidzein increased with age. Daily intake of daidzein was larger in equol-producer. The intestinal bacteria, which convert daidzein to equol were present in both equol producers and non-producers. However, the relative abundance and the prevalence of Asaccharobactercelatus and Slackiaisoflavoniconvertens were significantly higher in equol producers ...Continue Reading

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Citations

Jul 30, 2019·Journal of Cardiovascular Pharmacology·Kazuo Yamagata
Jul 16, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·L L FerreiraP M Spritzer
Jan 17, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Vanessa StadlbauerAngela Horvath
Mar 19, 2020·Nutrients·Priyanga SelvakumarAshakumary Lakshmikuttyamma
Sep 27, 2019·Nutrients·Sokratis StergiadisMichael R F Lee
Oct 30, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Akira SekikawaChendi Cui
Oct 23, 2020·Indian Journal of Microbiology·Natalia NaumovaMarsel Kabilov
Jun 24, 2021·Stroke; a Journal of Cerebral Circulation·Kimihiko YokosukaTomoki Hashimoto
Aug 28, 2021·International Journal of Environmental Research and Public Health·Mercedes Y Lacourt-VenturaMichelle M Martínez-Montemayor
Oct 2, 2021·Scientific Reports·Tomoko FujitaniKouji H Harada

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Software Mentioned

Statistical Package for the Social Science ( SPSS )
R Foundation for Statistical Computing
Metagenome
R
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