Daidzein regulates proinflammatory adipokines thereby improving obesity-related inflammation through PPARγ

Molecular Nutrition & Food Research
Yuri SakamotoKaoruko Iida

Abstract

Daidzein was recently reported to act like an activator of peroxisome proliferator-activated receptor γ (PPARγ) thereby enhancing differentiation of adipocytes. Although PPARγ plays a role in adipokine expression, it has not been well researched whether daidzein affects expression of adipokines. This study aimed to clarify the effects of daidzein on proinflammatory adipokines and adipose inflammation causing insulin resistance in obesity. 3T3-L1 adipocytes were treated with daidzein or genistein. Diet-induced obese C57BL/6J mice were fed high-fat high-sucrose diets with daidzein (1.0 g/kg chow) for 12 wk. The results showed that both isoflavones, especially daidzein, stimulated adipogenic differentiation in 3T3-L1 adipocytes with the activation of PPARγ. Daidzein also increased adiponectin expression and decreased MCP-1 expression with the consistent regulation of their secretion. In obese mice, daidzein inhibited hypertrophy in fat cell size and improved insulin sensitivity, concomitant with upregulation of PPARγ in fat tissue. Decreased expression of MCP-1 and TNF-α, and increased expression of adiponectin were also observed in adipose tissue of daidzein-fed mice. Additionally, daidzein administration significantly inhibited ...Continue Reading

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Citations

Jun 20, 2014·Nutrition Research and Practice·W Elaine Hardman
Apr 8, 2020·Bioscience, Biotechnology, and Biochemistry·Masaki AsanoTsuyoshi Tsuduki
Jan 4, 2017·PPAR Research·Soonkyu ChungMyoungsook Lee
Aug 23, 2020·Biomedicines·Shoib Sarwar SiddiquiCijo George Vazhappilly
Jul 28, 2020·European Journal of Pharmacology·Zuying YuMinglu Liang
Oct 26, 2018·European Journal of Medicinal Chemistry·Jiansong FangFeixiong Cheng
Mar 13, 2021·Frontiers in Pharmacology·Ram BhartiNeeraj Khatri

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