PMID: 8946260Dec 1, 1996Paper

Daily and photoperiodic melatonin binding changes in the suprachiasmatic nuclei, paraventricular thalamic nuclei, and pars tuberalis of the female Siberian hamster (Phodopus sungorus)

Journal of Biological Rhythms
J RecioMireille Masson-Pévet

Abstract

Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). Plasma melatonin concentrations were measured by radioimmunoassay, and the sexual status of the animals was established by visual inspection of vaginal smears and by weighing uteri after sacrifice. The SCN displayed neither daily nor photoperiod-dependent variations in specific binding. Melatonin receptors in these nuclei would be regulated neither by plasma melatonin nor by the light:dark cycle or sexual steroids. By contrast, melatonin receptor density in the PT displayed both strong daily (maximal values during the first half of the light period and minimal values during the night) and photoperiod-dependent (maximal values in LP) variations. These variations dependent on changes in the maximal binding (Bmax) without differences in the dissociation constant (Kd). Daily melatonin receptor densities in the PT of LP- and SP-exposed animals might be regulated by the dark:light transition but not by melatonin. Daily pr...Continue Reading

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Citations

Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·R R JiF Rupp
Aug 15, 1998·Journal of Chemical Neuroanatomy·S F PangS Y Shiu
Dec 25, 2003·Molecular Reproduction and Development·Ruslan Obłap, Bozenna Olszańska
Dec 3, 2014·Frontiers in Neuroendocrinology·Claudia P CoomansJohanna H Meijer
Dec 24, 2013·General and Comparative Endocrinology·Tomoko IkenoRandy J Nelson
Sep 15, 2018·Endocrine Reviews·José Cipolla-Neto, Fernanda Gaspar do Amaral
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·M J GerdinM L Dubocovich
Oct 24, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·David Stock, Eva Schernhammer
Jun 14, 2020·The International Journal of Neuroscience·Zeina S Malek, Louay M Labban

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