Daily blood hormone levels related to the luteinizing hormone surge in anovulatory cycles

Fertility and Sterility
C H Wu, F S Cowchock

Abstract

We have evaluated daily blood levels of gonadal steroids and trophic hormones in the cycles of four ovulatory and six anovulatory patients with a luteinizing hormone (LH) surge. The cycles of anovulatory nonhirsute patients were characterized by a premature and blunted LH surge and by low levels of follicle-stimulating hormone (FSH) throughout the study period in the face of normal tonic and peak levels of estrone and estradiol (E2). These observations, together with decreased levels of prolactin, suggest a hypothalamic pituitary abnormality as the cause of anovulation in these patients. The cycles of anovulatory hirsute patients were marked by a decrease in E2 production and a blunted and delayed E2 peak. Androgen levels were elevated throughout the cycle and may have a direct inhibitory effect on ovarian folliculogenesis. The LH/FSH ratio in the follicular phase was high in both groups of anovulatory patients when compared with ovulatory controls; however, the shifts in gonadotropin levels producing the increase in this ratio were different for these two groups.

Citations

Apr 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·J M Vargyas, R P Marrs
Dec 1, 1986·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·S JayaramanA R Sheth

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