PMID: 9426723Jan 14, 1998Paper

Daily dosing with flutamide or Casodex exerts maximal antiandrogenic activity

Urology
S LuoF Labrie

Abstract

Because the large increase in luteinizing hormone secretion induced by flutamide in the intact rat is not found in men, we have used castrated rats and mice supplemented with androstenedione (4-dione) instead of intact animals to measure the activity of the pure antiandrogens flutamide and Casodex. We first compared the effect of different schedules of administration of various doses of the two antiandrogens on prostate and seminal vesicle weights in the castrated rat and mice models. For both flutamide and Casodex, no consistent difference was found between the effects of once daily and thrice daily oral dosing in the rat. It was observed, however, that flutamide, especially at the high and therapeutically more effective doses, is about three times more potent than Casodex under both schedules of dosing. When flutamide was administered subcutaneously three times a day, twice a day, once a day, or once every second day in rats and mice, no difference was observed in the degree of inhibition achieved on prostate and seminal vesicle weights. The present data show that Casodex is about three times less potent than flutamide on the well-recognized parameters of androgen responsiveness in the rat, namely prostate and seminal vesicle...Continue Reading

References

May 1, 1992·The American Journal of Medicine·J L GomezF Labrie
Sep 15, 1991·Cancer·N Wilcken, M H Tattersall
Jul 1, 1991·Molecular and Cellular Endocrinology·F Labrie
Jan 22, 1990·Molecular and Cellular Endocrinology·C LabrieF Labrie
Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
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Jun 1, 1987·The Journal of Endocrinology·B J FurrH Tucker
Sep 1, 1967·European Journal of Pharmacology·R O NeriI A Tabachnick
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·J LaverdièreF Labrie
Jan 22, 2003·Drugs & Aging·Manfred P Wirth, Michael Froehner

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Citations

Apr 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeremy O JonesMarc I Diamond
Jul 22, 2006·American Journal of Therapeutics·Steven R AlbertsCharles L Loprinzi
Dec 24, 2005·Shock·Mashkoor A ChoudhryIrshad H Chaudry
Nov 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Helen BainesFrancis J P Ebling
Oct 25, 2007·International Journal of Cancer. Journal International Du Cancer·Zhao Zhigang, Shen Wenlu
Jul 5, 2005·Expert Opinion on Investigational Drugs·P Schellhammer
Jun 30, 2004·Journal of Andrology·Jeremiah C MurphyMartha K Terris
Apr 6, 2018·JCI Insight·Mauro Sb SilvaRebecca E Campbell
Oct 17, 2020·Journal of the American Heart Association·Yasushi TashimaMichael P Fischbein
Nov 9, 2005·Molecular Cancer Therapeutics·Romyla IlaganMichael Carey
Jun 29, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yuehui ZhangHåkan Billig

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