Abstract
We evaluated the daily energy balance and main substrate utilization in Type 1 insulin dependent diabetic patients and healthy volunteers. Ten patients with Type 1 diabetes mellitus and eight healthy volunteers were studied. Diabetic patients were well controlled under intensive insulin treatment (0.6 UI/kg body weight, HbA1c = 5.5 +/- 0.7%). During the 30 hours each subject spent in the respiration chamber VO2, VCO2, respiratory quotient, daily energy intake, 24-hour, day-time, night-time and basal energy expenditure as well as energy expenditure during exercise (at 40% maximal exercise capacity), main substrate oxidation (carbohydrates, lipids and proteins) and overall diet-induced thermogenesis, were measured. The results were corrected for 24-hour urinary nitrogen loss. Diet-induced thermogenesis, expressed as percent of energy intake, was found to be significantly lower in diabetic patients than in control subjects (6.69 +/- 1.29% vs 11.8 +/- 4.71% of energy intake, p < 0.05). A negative correlation was found between diet-induced thermogenesis and daily average glycemia for diabetic patients (r = -0.65, p < 0.01). Energy expenditure during exercise, calculated in terms of net work efficiency, was not different between the ...Continue Reading
References
Oct 1, 1976·The American Journal of Clinical Nutrition·M L Kaplan, G A Leveille
Nov 20, 1975·The New England Journal of Medicine·P Felig, J Wahren
Jul 1, 1991·The American Journal of Clinical Nutrition·J O HillH L Greene
Apr 1, 1990·The American Journal of Clinical Nutrition·G Livesey
Aug 1, 1989·The American Journal of Clinical Nutrition·Y SchutzE Jéquier
Mar 1, 1988·Metabolism: Clinical and Experimental·E Ferrannini
Apr 1, 1988·The American Journal of Clinical Nutrition·G Livesey, M Elia
Jul 10, 1986·The New England Journal of Medicine·C BogardusP P Moll
Dec 1, 1986·The Journal of Clinical Investigation·E RavussinC Bogardus
Sep 1, 1985·The Journal of Clinical Investigation·J P FlattE Jéquier
Apr 1, 1974·The Journal of Clinical Investigation·G AhlborgJ Wahren
Sep 1, 1983·The Journal of Clinical Investigation·E RavussinE A Sims
Sep 1, 1984·The American Journal of Clinical Nutrition·Y SchutzE Jéquier
Nov 1, 1983·The American Journal of Clinical Nutrition·T BessardE Jéquier
Dec 1, 1983·The American Journal of Clinical Nutrition·E Jéquier, Y Schutz
Nov 1, 1982·Diabetes·A GolayE Jéquier
Mar 1, 1982·The American Journal of Clinical Nutrition·E RavussinE Jéquier
Jan 1, 1981·Diabetologia·J P FelberE Jéquier
Jun 1, 1980·The American Journal of Clinical Nutrition·P WebbS J Troutman
Citations
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A V GrecoG Gasbarrini
Apr 5, 2002·Computers in Biology and Medicine·S MarinoG Mingrone
Nov 13, 2002·Gut·A V GrecoG Gasbarrini
May 13, 2003·Obesity Research·Geltrude MingroneHubert Vidal
Jun 16, 2015·BioMed Research International·Shin FujimakiTomoko Kuwabara
Mar 30, 2004·Diabetes·Menotti CalvaniGeltrude Mingrone
Oct 19, 2017·International Journal of Molecular Sciences·Shin Fujimaki, Tomoko Kuwabara
Jul 31, 2018·Endocrine Reviews·Karen D CorbinUNKNOWN Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON)
Sep 28, 2018·Frontiers in Physiology·Suhail RasoolJeganathan R Babu
May 21, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Zhe ZhangShuzhe Ding
Jun 3, 2021·Biomolecules·Natalya V KhromovaRenata I Dmitrieva
Sep 6, 2018·Gene·Xueyu YanGanqiu Lan