PMID: 9435594Jan 22, 1998Paper

Daily exercise attenuates the sympathetic component of the arterial baroreflex control of heart rate

The American Journal of Physiology
H L Collins, S E DiCarlo

Abstract

The influence of daily spontaneous running (DSR) on the sympathetic (SC) and parasympathetic components of the arterial baroreflex control of heart rate (HR) was examined in 16 female Long Evans rats [8 sedentary (SED) and 8 DSR]. After 8-9 wk of SED control or DSR, animals were chronically instrumented with arterial and venous catheters. DSR resulted in an increased heart weight-to-body weight ratio (2.71 +/- 0.11 vs. 3.09 +/- 0.09 g/kg) and a resting bradycardia (378 +/- 6 vs. 330 +/- 5 beats/min). Arterial baroreflex function was examined during ramp infusions of phenylephrine and sodium nitroprusside under the following three experimental conditions: 1) control, 2) after beta 1-adrenergic receptor blockade (beta 1-X), and 3) after muscarinic-cholinergic receptor blockade (M-X). Arterial baroreflex function parameters were compared between SED and DSR rats. In the control condition, DSR attenuated the range (182 +/- 15 vs. 124 +/- 18 beats/min), maximum HR (464 +/- 9 vs. 394 +/- 15 beats/min), and maximal gain (Gmax; 5.57 +/- 0.42 vs. 3.2 +/- 0.45 beats.min-1.mmHg-1). Similarly, after M-X, DSR attenuated the range (84 +/- 5 vs. 62 +/- 8 beats/min), maximum HR (449 +/- 11 vs. 412 +/- 11 beats/min), and Gmax (2.73 +/- 0.37 vs....Continue Reading

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Citations

Aug 27, 2005·Journal of Applied Physiology·Amanda J NelsonGary A Iwamoto
Oct 9, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Heidi L CollinsStephen E Dicarlo
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven L Bealer
Jan 1, 2009·Stress : the International Journal on the Biology of Stress·Angela J Grippo, Alan Kim Johnson
Oct 9, 2012·Journal of Applied Physiology·Efrat Kurtzwald-JosefsonMichael Arad
Dec 1, 2001·Clinical and Experimental Hypertension : CHE·H L CollinsS E DiCarlo
Mar 9, 2002·Clinical and Experimental Hypertension : CHE·S E DiCarloV K Yeragani
May 12, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maryetta D Dombrowski, Patrick J Mueller
Apr 2, 2003·Neuroscience and Biobehavioral Reviews·Angela J Grippo, Alan Kim Johnson

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