Daily injections of melatonin entrain the circadian activity rhythms of nocturnal rats but not diurnal chipmunks

Brain Research
N MurakamiT Murakami

Abstract

It is well known that daily injections of melatonin entrain the free-running rhythms of nocturnal rodents (rats and hamster) and diurnal sauropside (birds and lizard). Here, we asked whether daily injections of melatonin entrain the free-running rhythm of the chipmunk, a diurnal rodent, and, if they do, is the phase relationship between the time of injection and onset of the activity interval similar to that in sauropside rather than that of nocturnal rodents? Contrary to our expectations, daily injections of melatonin did not entrain the free-running rhythm in 9 of 10 chipmunks, even when a high dose of melatonin (1 mg/kg, b.wt.) was used. These results indicate that the entraining effect of daily injections of melatonin on free-running rhythm varies among mammalian species.

Citations

Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·X M LiF Lévi
Feb 24, 2001·Nature·M NakazatoS Matsukura
Nov 6, 2004·The Journal of Veterinary Medical Science·Keiko NakaharaNoboru Murakami
Mar 21, 2013·Journal of Animal Physiology and Animal Nutrition·T NasoA El-Kirdasy
Oct 12, 2000·Biochemical and Biophysical Research Communications·M NakazatoS Matsukura
Nov 16, 2001·Biochemical and Biophysical Research Communications·R HanadaT Sakata

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