Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice

Journal of Pharmacological Sciences
Kakeru OzakiEiichi Hinoi

Abstract

Although β-cryptoxanthin, a xanthophyll carotenoid, has been shown to exert an anabolic effect on bone calcification, little attention has been paid thus far to the precise mechanism of bone remodeling. Daily oral administration of β-cryptoxanthin significantly inhibited osteoclastic activation as well as reduction of bone volume in ovariectomized mice. In vitro studies revealed that β-cryptoxanthin inhibited differentiation and maturation of osteoclasts by repression of the nuclear factor-κB-dependent transcriptional pathway. Our results suggest that supplementation with β-cryptoxanthin would be beneficial for prophylaxis and for therapy of metabolic bone diseases associated with abnormal osteoclast activation.

References

Feb 6, 2004·Biological & Pharmaceutical Bulletin·Satoshi UchiyamaMasayoshi Yamaguchi
Nov 3, 2006·Biochemical Pharmacology·Nobuaki MoriguchiYukio Yoneda
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Gerard KarsentyCarmine Settembre
Oct 13, 2010·Annual Review of Pathology·Xu Feng, Jay M McDonald
Dec 23, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eiichi HinoiYukio Yoneda
Jun 19, 2012·Trends in Endocrinology and Metabolism : TEM·Tomoki NakashimaHiroshi Takayanagi
Mar 29, 2014·Cancer Science·Kyoung-Bok Min, Jin-Young Min
Mar 7, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Minoru Sugiura

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Citations

Sep 7, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Keiko UnnoHiroshi Yamada
Jan 24, 2017·Bioscience, Biotechnology, and Biochemistry·Gyujin ParkEiichi Hinoi
Jul 5, 2017·Biological & Pharmaceutical Bulletin·Gyujin ParkEiichi Hinoi
Jun 13, 2018·Marine Drugs·Javier Torregrosa-CrespoRosa María Martínez-Espinosa

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