Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task

British Journal of Pharmacology
David R MaguireCharles P France

Abstract

Repeated administration of a μ opioid receptor agonist can enhance some forms of impulsivity, such as delay discounting. However, it is unclear whether repeated administration alters motor impulsivity. We examined the effects of acute administration of morphine and amphetamine prior to and during daily morphine administration in rats responding under a five-choice serial reaction time task. Rats (n = 5) were trained to detect a brief flash of light presented randomly in one of five response holes; responding in the target hole delivered food, whereas responding in the wrong hole or responding prior to illumination of the target stimulus (premature response) initiated a timeout. Premature responding served as an index of motor impulsivity. Administered acutely, morphine (0.1-10 mg·kg(-1) , i.p.) increased omissions and modestly, although not significantly, premature responding without affecting response accuracy; amphetamine (0.1-1.78 mg·kg(-1) , i.p.) increased premature responding without changing omissions or response accuracy. After 3 weeks of 10 mg·kg(-1) ·day(-1) morphine, tolerance developed to its effects on omissions whereas premature responding increased approximately fourfold, compared with baseline. Effects of amphet...Continue Reading

References

Nov 7, 1999·Psychopharmacology·J L Evenden
Apr 20, 2000·European Journal of Pharmacology·I P StolermanM Shoaib
Nov 3, 2001·The American Journal of Psychiatry·F G MoellerA C Swann
Jan 31, 2004·Psychopharmacology·Artur K KieresJerry B Richards
Jul 29, 2005·Journal of the Experimental Analysis of Behavior·Raymond C Pitts, A Patrick McKinney
Feb 2, 2006·Biological Psychiatry·Luke ClarkBarbara J Sahakian
Aug 1, 2006·Addictive Behaviors·Antonio J Verdejo-GarcíaMiguel Pérez-García
Dec 8, 2007·Drug and Alcohol Dependence·F PassettiM King
Apr 2, 2008·Drug and Alcohol Dependence·Donald M DoughertyCharles W Mathias
Jul 5, 2008·Psychopharmacology·Jennifer L Perry, Marilyn E Carroll
May 14, 2009·Psychopharmacology·Tommy PattijAnton N M Schoffelmeer
Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joost WiskerkeTommy Pattij
Feb 15, 2011·Pharmacology, Biochemistry, and Behavior·Seth C HartyRobert Ranaldi
Feb 26, 2011·Journal of Pharmacology & Pharmacotherapeutics·Carol KilkennyDouglas G Altman
Jun 1, 2008·Current Protocols in Pharmacology·Guy A Higgins, Nathalie Breysse
May 17, 2012·Psychopharmacology·Colin Harvey-LewisKeith B J Franklin
Jul 10, 2012·Neuroscience and Biobehavioral Reviews·A BaldacchinoK Matthews
Sep 5, 2012·Journal of Pharmacological and Toxicological Methods·David R MaguireCharles P France
Mar 7, 2013·Current Opinion in Neurobiology·Tommy Pattij, Taco J De Vries
Apr 5, 2013·Journal of the Experimental Analysis of Behavior·Amy K EppolitoLisa R Gerak
Nov 16, 2013·Nucleic Acids Research·Adam J PawsonUNKNOWN NC-IUPHAR
Oct 29, 2014·Behavioural Pharmacology·Colin Harvey-LewisKeith B J Franklin
Feb 14, 2015·Current Addiction Reports·Jessica WeaferHarriet de Wit
May 13, 2015·British Journal of Pharmacology·John C McGrath, Elliot Lilley
Jun 27, 2015·British Journal of Pharmacology·Michael J CurtisJohn C McGrath
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCgtp Collaborators

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