Daily multivitamins with iron to prevent anemia in high-risk infants: a randomized clinical trial

Pediatrics
P L GeltmanH Bauchner

Abstract

The goal of this study was to assess the effectiveness of multivitamins with iron as prophylaxis against iron deficiency and anemia in infancy. The study was a double-blinded, randomized, pragmatic, clinical trial conducted at 3 urban primary care clinics. Subjects included healthy, full-term infants who were enrolled at their 6-month well-child visit. Infants were randomly assigned to receive standard-dose multivitamins with or without iron (10 mg/day). Parents administered multivitamins by mouth daily for 3 months. Laboratory results at 9 months of age were analyzed for the presence of anemia and/or iron deficiency. Anemia was defined as hemoglobin level <11.0 g/dL. Iron deficiency was initially defined as any abnormal laboratory value of the following: mean corpuscular volume combined with red cell distribution width or zinc protoporphyrin (with blood lead level <10 microg/dL) for most subjects and ferritin, transferrin saturation, or reticulocyte hemoglobin content for a subset. Subsequent analyses defined iron deficiency as any 2 abnormalities of the above laboratory outcomes, except hemoglobin. The control (n = 138) and intervention (n = 146) groups were equivalent with respect to all important sociodemographic and nutrit...Continue Reading

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Citations

Jan 5, 2011·Nutrition Reviews·Annelies van ZwolRuurd M van Elburg
Apr 15, 2014·Early Human Development·Julie BoyerJean-Christophe Rozé
Jan 4, 2013·Nutrition Reviews·Chang Cao, Kimberly O O'Brien
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Sep 9, 2005·American Journal of Law & Medicine·Michael A McCann
Apr 1, 2015·Pediatrics·Marian S McDonaghChristina Bougatsos

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