Abstract
The goal of this study was to assess the effectiveness of multivitamins with iron as prophylaxis against iron deficiency and anemia in infancy. The study was a double-blinded, randomized, pragmatic, clinical trial conducted at 3 urban primary care clinics. Subjects included healthy, full-term infants who were enrolled at their 6-month well-child visit. Infants were randomly assigned to receive standard-dose multivitamins with or without iron (10 mg/day). Parents administered multivitamins by mouth daily for 3 months. Laboratory results at 9 months of age were analyzed for the presence of anemia and/or iron deficiency. Anemia was defined as hemoglobin level <11.0 g/dL. Iron deficiency was initially defined as any abnormal laboratory value of the following: mean corpuscular volume combined with red cell distribution width or zinc protoporphyrin (with blood lead level <10 microg/dL) for most subjects and ferritin, transferrin saturation, or reticulocyte hemoglobin content for a subset. Subsequent analyses defined iron deficiency as any 2 abnormalities of the above laboratory outcomes, except hemoglobin. The control (n = 138) and intervention (n = 146) groups were equivalent with respect to all important sociodemographic and nutrit...Continue Reading
References
Feb 1, 1991·The American Journal of Clinical Nutrition·D SiegenbergF Mayet
May 1, 1991·The Journal of Pediatrics·F PizarroT Walter
Apr 1, 1990·Paediatric and Perinatal Epidemiology·J ColomerC Alvarez-Dardet
Jan 1, 1980·The American Journal of Clinical Nutrition·P R DallmanA Stekel
Jan 1, 1993·Annual Review of Nutrition·E Pollitt
Sep 1, 1995·Nutrition Reviews·T H Bothwell
Feb 1, 1997·Archives of Disease in Childhood·F ChildsL N Livera
Apr 1, 1997·Nutrition Reviews·E Pollitt
Oct 29, 1997·Archives of Pediatrics & Adolescent Medicine·A N Eden, M A Mir
Apr 3, 1998·Pediatrics·S M YuP Gergen
Nov 14, 1997·The American Journal of Clinical Nutrition·P PreziosiS Hercberg
Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·M D EngelmannK F Michaelsen
Mar 24, 1999·Current Opinion in Hematology·I BlotG Tchernia
Jun 22, 1999·JAMA : the Journal of the American Medical Association·C BrugnaraO Platt
Jul 16, 1999·International Journal of Epidemiology·J KilbrideD Jerwood
Aug 5, 1999·American Journal of Public Health·S J BlumbergR R Briefel
Feb 13, 2001·BMJ : British Medical Journal·P LittleJ Dunleavey
Mar 20, 2001·Archives of Pediatrics & Adolescent Medicine·D L BogenJ R Serwint
Apr 20, 2001·JAMA : the Journal of the American Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards of Reporting Trials)
May 23, 2001·Pediatrics·B SherryR Yip
May 9, 2001·The Journal of Pediatrics·M DomellöfB Lönnerdal
Oct 30, 2001·Clinical Pediatrics·P L GeltmanH Bauchner
Nov 6, 2001·The Journal of Nutrition·M A Dijkhuizen Muhilal
Aug 7, 2002·The Journal of Nutrition·Saskia De PeeSoewarta Kosen
Jan 10, 2003·The Journal of Pediatrics·Robert O WrightHoward Hu
Apr 18, 2003·The New England Journal of Medicine·Richard L CanfieldBruce P Lanphear
Citations
Jan 5, 2011·Nutrition Reviews·Annelies van ZwolRuurd M van Elburg
Mar 20, 2010·BMC Public Health·Meera K ChhaganMichael L Bennish
Apr 15, 2014·Early Human Development·Julie BoyerJean-Christophe Rozé
Jan 4, 2013·Nutrition Reviews·Chang Cao, Kimberly O O'Brien
Dec 29, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·L UijterschoutF Brus
Dec 19, 2014·Maternal & Child Nutrition·Souheila AbbeddouKenneth H Brown
Dec 30, 2008·The Journal of Pediatrics·Paul L GeltmanHoward Bauchner
Jun 24, 2008·The Journal of Pediatrics·Nicole L Baumann-BlackmorePamela J Kling
Nov 16, 2005·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Sharon M Coyer
Aug 9, 2016·Medicine·Berhanu Elfu Feleke
Dec 6, 2016·Nutrients·Nicolai PetryFabian Rohner
Oct 1, 2008·Cadernos de saúde pública·Maria Claret Costa Monteiro HadlerVinícius Montenegro Torres
Jun 17, 2008·São Paulo Medical Journal = Revista Paulista De Medicina·André Fernando ShibukawaRosana Fiorini Puccini
Jul 3, 2020·The American Journal of Clinical Nutrition·Katherine M DelaneyKimberly O O'Brien
Apr 19, 2020·Maternal and Child Health Journal·Mayri Sagady LeslieJessica Greene
Sep 2, 2016·The American Journal of Clinical Nutrition·Yuan RuKimberly O O'Brien
Sep 9, 2005·American Journal of Law & Medicine·Michael A McCann
Sep 4, 2007·Pediatrics·Jane M BrotanekGlenn Flores
Apr 1, 2015·Pediatrics·Marian S McDonaghChristina Bougatsos