Daily nutritional dose supplementation with antioxidant nutrients and phytochemicals improves DNA and LDL stability: a double-blind, randomized, and placebo-controlled trial

Nutrients
You Jin KimOran Kwon

Abstract

Reactive oxygen species are important risk factors for age-related diseases, but they also act as signaling factors for endogenous antioxidative defense. The hypothesis that a multi-micronutrient supplement with nutritional doses of antioxidant nutrients and phytochemicals (MP) may provide protection against oxidative damage and maintain the endogenous antioxidant defense capacity was assessed in subjects with a habitually low intake of fruits and vegetables. In a randomized, placebo-controlled, and parallel designed trial, 89 eligible subjects were assigned to either placebo or MP for eight weeks. Eighty subjects have completed the protocol and included for the analysis. MP treatment was superior at increasing serum folate (p < 0.0001) and resistance to DNA damage (p = 0.006, tail intensity; p = 0.030, tail moment by comet assay), and LDL oxidation (p = 0.009) compared with the placebo. Moreover, the endogenous oxidative defense capacity was not weakened after MP supplementation, as determined by the levels of glutathione peroxidase (p = 0.442), catalase (p = 0.686), and superoxide dismutase (p = 0.804). The serum folate level was negatively correlated with DNA damage (r = -0.376, p = 0.001 for tail density; r = -0.329, p = 0....Continue Reading

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Methods Mentioned

BETA
electrophoresis
enzyme-linked immunosorbent assay
sandwich immunoassay
ELISA
MDA

Software Mentioned

CAN
COMET
pro
Statistical Analysis Systems
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