Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.

Cell Stem Cell
Karin GolanTsvee Lapidot

Abstract

Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production of mature leukocytes and blood replenishment. We found two daily peaks of BM HSPC activity that are initiated by onset of light and darkness providing this coupling. Both peaks follow transient elevation of BM norepinephrine and TNF secretion, which temporarily increase HSPC reactive oxygen species (ROS) levels. Light-induced norepinephrine and TNF secretion augments HSPC differentiation and increases vascular permeability to replenish the blood. In contrast, darkness-induced TNF increases melatonin secretion to drive renewal of HSPCs and LT-HSC potential through modulating surface CD150 and c-Kit expression, increasing COX-2/αSMA+ macrophages, diminishing vascular permeability, and reducing HSPC ROS levels. These findings reveal that light- and darkness-induced daily bursts of norepinephrine, TNF, and melatonin within the BM are essential for synchronized mature blood cell production and HSPC pool repopulation.

Citations

Apr 13, 2019·Immunological Reviews·Sandra Zehentmeier, João P Pereira
Mar 23, 2019·Blood·Itziar CossíoAndrés Hidalgo
Oct 27, 2018·Blood·Andrés García-GarcíaSimón Méndez-Ferrer
Apr 25, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luís LeitãoMeriem Lamghari
Apr 14, 2020·Journal of Pineal Research·David J Kennaway
Dec 11, 2019·Immunology·Matthew Baxter, David W Ray
Apr 15, 2020·Nature Communications·Philip E D ChungEldad Zacksenhaus
Sep 15, 2020·Frontiers in Cellular and Infection Microbiology·Pooja ShivshankarRick A Wetsel
May 30, 2019·Cancer Cell International·Mugdha SharmaSweta Srivastava
Jun 9, 2020·Frontiers in Immunology·Andrés García-García, Simón Méndez-Ferrer
Jul 28, 2020·Frontiers in Immunology·Sarah Leach, Kazuhiro Suzuki
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Linping HuTao Cheng
Jul 1, 2020·F1000Research·Claire Fielding, Simón Méndez-Ferrer
Jan 9, 2020·Stem Cell Reviews and Reports·Azin SamimiElahe Khodadi
May 11, 2019·International Journal of Molecular Sciences·Ellen PaatelaNobuaki Kikyo
Oct 7, 2020·Annual Review of Cell and Developmental Biology·Joseph Lewis BedontAmita Sehgal
Jan 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·G S KinkerP A C M Fernandes
Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Heather Ballance, Bokai Zhu
Feb 5, 2021·Haematologica·Orit KolletTsvee Lapidot
Dec 29, 2020·General and Comparative Endocrinology·Stefanny Christie Monteiro TitonRegina P Markus
Nov 5, 2020·Stem Cell Reviews and Reports·Hal E BroxmeyerMaegan L Capitano
Feb 9, 2021·Frontiers in Immunology·Monika OkuliarovaMichal Zeman
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Dorothée GirardSébastien Banzet
Nov 14, 2020·Genome Biology·Luis Enrique Cortés-HernándezCatherine Alix-Panabières
Mar 23, 2021·International Immunology·Akiko NakaiKazuhiro Suzuki
Jun 6, 2020·Cell Stem Cell·Salvador Aznar Benitah, Patrick-Simon Welz
Jun 16, 2021·The Journal of Experimental Medicine·Tobias Kull, Timm Schroeder
Jul 24, 2021·Stem Cell Reports·Nir BujanoverRoi Gazit
Aug 4, 2021·Science China. Life Sciences·Shiru YuanTao Cheng
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Julia FröbelRobert A J Oostendorp
Aug 27, 2021·Journal of Pineal Research·Ko-Hsiu LuShun-Fa Yang
Oct 24, 2021·Experimental Hematology·Nicole Mende, Elisa Laurenti
Jan 29, 2022·Nature Communications·Claire FieldingSimón Méndez-Ferrer

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