Daily or on demand oral TDF/FTC for HIV pre-exposure prophylaxis: experience from an hospital-based clinic in France

AIDS
Marion NoretJean-Michel Molina

Abstract

On Demand oral TDF/FTC has been approved for pre-exposure prophylaxis (PrEP) in men who have sex with men (MSM) in France following the results of clinical studies but data are limited on real-world experience. A single center, open-label, prospective cohort study that recruited people at high risk of HIV infection in Paris. Subjects were enrolled in a single hospital-based outpatient clinic and were proposed to start PrEP with daily or on demand TDF/FTC. At baseline and every 3 months thereafter subjects were tested for HIV and creatinine plasma levels and data on sexual behavior, other sexually transmitted infections (STIs), and tolerability were collected. From November 10, 2015 to April 30, 2017, 1069 subjects were screened and 1049 (98.1%) started PrEP. Median age was 36 years, 99.4% were MSM with a median number of partners of 10, and 793 (75.6%) opted for on demand PrEP. Over 486 person-years (PY) of follow-up, 4 HIV-infection were diagnosed in poorly or non-adherent subjects (incidence: 0.82/100 PY). Rate of condomless sex at last intercourse increased from 53.3% at baseline to 79% at month 12 (p < 10) but increase in bacterial STI rates was modest (14.6% at baseline vs 19.2% at month 12, (p < 10). Most adverse events w...Continue Reading

References

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Citations

Jul 25, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jennifer VellozaUNKNOWN HPTN 067/ADAPT Study Team
Oct 16, 2019·Journal of the International AIDS Society·Hanne Ml ZimmermannUNKNOWN Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Consortium (H-TEAM)

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