Daily oral oleoyl-estrone gavage induces a dose-dependent loss of fat in Wistar rats

Obesity Research
M del Mar GrasaM Alemany

Abstract

To establish whether single daily oral doses of oleoyl-estrone result in dose-dependent slimming effects on normal weight rats, and to determine the changes in energy parameters induced by this treatment. The effects of a daily oral gavage of oleoyl-estrone (0, 0.2, 0.5, 1, 2, 5, 10, and 20 micromol/kg per day) in 0.2 ml of sunflower oil given over a 10-day period were studied in groups, each of which contained six adult female Wistar rats initially weighing 190 to 230 g. A group of intact control rats receiving no gavage was included for comparison. Body weight and food intake were measured daily. Rats were killed on day 10 of treatment, and body composition (protein nitrogen, lipids, and water), liver lipids, and plasma parameters (glucose, triacylglycerols, total cholesterol, free fatty acids, 3-hydroxybutyrate, urea, aspartate, alanine transaminases, insulin, leptin, and free and acyl-estrone) were measured. The administration of oleoyl-estrone resulted in a dose-dependent loss of body fat, because of a partly maintained energy expenditure combined with decreased food intake. The differences in the energy budget were met by internal fat pools. The changes recorded did not affect the levels of the main plasma energy homeosta...Continue Reading

References

Aug 1, 1994·The British Journal of Nutrition·I RafecasM Alemany
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Jul 1, 1997·Analytical Biochemistry·A ArdévolM Alemany
Nov 5, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F BaladaM Alemany
Jan 24, 1998·Archives of Physiology and Biochemistry·F BaladaM Alemany
Feb 5, 1998·Molecular and Cellular Biochemistry·D SanchisM Alemany
May 5, 1998·Life Sciences·D SanchisM Alemany
May 26, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C AdánM Alemany
Jun 3, 1999·European Journal of Nutrition·M EsteveM Alemany
Jul 9, 1999·Clinical Endocrinology·J M Fernández-RealM Alemany
Feb 2, 2000·European Journal of Nutrition·X RemesarM Alemany
Oct 6, 2000·Endocrine Research·C CabotM Alemany
Jan 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·X RemesarM Alemany
Aug 7, 2001·Life Sciences·M EsteveM Alemany

❮ Previous
Next ❯

Citations

Dec 24, 2002·The British Journal of Nutrition·James O Hill, John C Peters
Nov 10, 2005·The British Journal of Nutrition·Anna SalasXavier Remesar
Jun 24, 2008·Reproductive Biology and Endocrinology : RB&E·Beatriz García-PeláezXavier Remesar
Jun 30, 2007·Journal of Endocrinological Investigation·C CabotM Alemany
Mar 26, 2008·Journal of Endocrinological Investigation·M Serrano-MuñozM Alemany
Mar 28, 2009·European Journal of Nutrition·María del Mar RomeroMarià Alemany
Mar 28, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·M M RomeroM Alemany
Mar 3, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·R Ferrer-LorenteM Alemany
Feb 12, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Ruth VilàMarià Alemany
Jan 1, 2010·Obesity Research & Clinical Practice·Maria Del Mar RomeroJosé-Antonio Fernández-López
Jun 24, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Marta SerranoMarià Alemany
Feb 3, 2011·Medicinal Research Reviews·Xavier RemesarMarià Alemany
Oct 7, 2004·Steroids·Raquel Ferrer-LorenteMarià Alemany
Oct 24, 2006·Life Sciences·Anna SalasMontserrat Esteve
May 3, 2005·European Journal of Pharmacology·Raquel Ferrer-LorenteMarià Alemany
Mar 12, 2009·Bioscience Reports·María Del Mar RomeroMontserrat Esteve
Jun 15, 2007·Journal of Pharmacological Sciences·Raquel Ferrer-LorenteMarià Alemany
Jul 18, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·X RemesarM Alemany
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M BlayM Alemany
Aug 26, 2004·Journal of Dairy Science·B García-PeláezM Alemany
Sep 4, 2009·Current Opinion in Gastroenterology·Mitchell L Schubert
Mar 27, 2010·Obesity·Sabine StrassburgDiego Perez-Tilve
Jan 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M M RomeroM Alemany
Jan 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C CabotM Alemany
Mar 29, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R M MassanésM Alemany
Apr 4, 2002·Drugs·José-Antonio Fernández-LópezMarià Alemany

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
X RemesarM Alemany
© 2021 Meta ULC. All rights reserved