Daily rhythms in plasma levels of homocysteine

Journal of Circadian Rhythms
Lena Lavie, Peretz Lavie

Abstract

BACKGROUND: There is accumulated evidence that plasma concentration of the sulfur-containing amino-acid homocysteine (Hcy) is a prognostic marker for cardiovascular morbidity and mortality. Both fasting levels of Hcy and post methionine loading levels are used as prognostic markers. The aim of the present study was to investigate the existence of a daily rhythm in plasma Hcy under strictly controlled nutritional and sleep-wake conditions. We also investigated if the time during which methionine loading is performed, i.e., morning or evening, had a different effect on the resultant plasma Hcy concentration. METHODS: Six healthy men aged 23-26 years participated in 4 experiments. In the first and second experiments, the daily rhythm in Hcy as well as in other amino acids was investigated under a normal or an inverse sleep-wake cycle. In the third and fourth, Hcy concentrations were investigated after a morning and evening methionine loading. To standardize food consumption in the first two experiments, subjects received every 3 hours 150 ml of specially designed low-protein liquid food (Ensure(R) formula). RESULTS: In both the first and second experiments there was a significant daily rhythm in Hcy concentrations with a mid-day n...Continue Reading

References

Mar 1, 1976·Metabolism: Clinical and Experimental·W P SteffeeV R Young
Jul 25, 1968·The New England Journal of Medicine·R J WurtmanF F Larin
Sep 1, 1968·Metabolism: Clinical and Experimental·R D FeiginW R Beisel
Jul 29, 1967·Nature·R D FeiginW R Beisel
Mar 1, 1996·Journal of the American College of Cardiology·E L MayerK Robinson
Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
Jul 24, 1997·The New England Journal of Medicine·O NygårdS E Vollset
Dec 31, 1997·The New England Journal of Medicine·S Moll
Jul 17, 1998·The Journal of Laboratory and Clinical Medicine·R van der GriendJ D Banga
Jun 9, 1999·Scandinavian Journal of Work, Environment & Health·H Bøggild, A Knutsson
Aug 17, 1999·Annual Review of Nutrition·J Selhub
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·J C ChambersJ S Kooner
Nov 14, 2000·The American Journal of Cardiology·W F BremnerL E Scheving
Feb 24, 2001·Reviews on Environmental Health·A Knutsson, H Bøggild
Sep 11, 2002·Journal of Pineal Research·Giyasettin BaydasHaluk Kelestimur
Oct 2, 2002·Journal of the American College of Cardiology·Ahmed TawakolHenry Gewirtz
Aug 26, 2003·Occupational and Environmental Medicine·P J F MartinsS Tufik
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

❮ Previous
Next ❯

Citations

Mar 19, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Makoto SuzukiMasaru Yoshida
Jul 9, 2014·Metabolites·Shin NishiumiMasaru Yoshida
Oct 13, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul GerdhemKristina Akesson
Apr 25, 2007·Chronobiology International·Dominikus BönschStefan Bleich
Feb 11, 2014·Molecular Biology Reports·Basil PaulMoinak Banerjee
Apr 25, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tianpeng ZhangBaojian Wu
Jul 14, 2012·PloS One·Shin NishiumiMasaru Yoshida

❮ Previous
Next ❯

Software Mentioned

Cosinor

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.