Daily running for 2 wk and mRNAs for cytochrome c and alpha-actin in rat skeletal muscle.

The American Journal of Physiology
P R MorrisonF W Booth

Abstract

The purpose of the study was to determine whether daily running durations that were 7-14% of the durations employed in the chronic stimulation protocols (consisting of 24 h of daily indirect electrical stimulation of skeletal muscles) still resulted in increases in a mitochondrial protein mRNA. Adult female rats were run 100 min/day on motor-driven treadmills for 2 wk. Documentation that rats underwent the stated training program was obtained by a 30-41% increase in citrate synthase activity in hindlimb muscles after 2 wk of the training. Cytochrome c mRNA was increased 17-56% in hindlimb muscles after the 2-wk training program. Thus shorter durations of exercise (100 min/day rather than 24 h/day) can increase cytochrome c mRNA. alpha-Actin mRNA increased 61-62% in fast-twitch muscles in the hindlimbs of the same rats that underwent the 2 wk of run training but did not increase in the predominantly slow-twitch soleus muscle. The increase in alpha-actin mRNA was unexpected, since it is well known that this type of physical exercise does not increase the size of fast-twitch skeletal muscle.

References

Apr 1, 1975·The American Journal of Physiology·R H FittsJ O Holloszy
Sep 30, 1970·Biochemical and Biophysical Research Communications·J O HolloszyP A Molé
Feb 1, 1972·The American Journal of Physiology·K M BaldwinJ O Holloszy
Oct 1, 1966·Analytical Biochemistry·J B Le Pecq, C Paoletti

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Citations

May 17, 2017·Cold Spring Harbor Perspectives in Medicine·Christopher G R Perry, John A Hawley
Feb 10, 1999·The American Journal of Physiology·D S O'NeillJ A Houmard
Jul 11, 1998·Biochimica Et Biophysica Acta·T MurakamiN Fujitsuka

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