Daily Supplementation of L-Glutamine in Atrial Fibrillation Patients: The Effect on Heat Shock Proteins and Metabolites.

Cells
Roeliene StarreveldNatasja M S de Groot

Abstract

Pharmaco-therapeutic strategies of atrial fibrillation (AF) are moderately effective and do not prevent AF onset and progression. Therefore, there is an urgent need to develop novel therapies. Previous studies revealed heat shock protein (HSP)-inducing compounds to mitigate AF onset and progression. Such an HSP inducing compound is L-glutamine. In the current study we investigate the effect of L-glutamine supplementation on serum HSP27 and HSP70 levels and metabolite levels in patients with AF patients (n = 21). Hereto, HSP27 and HSP70 levels were determined by ELISAs and metabolites with LC-mass spectrometry. HSP27 levels significantly decreased after 3-months of L-glutamine supplementation [540.39 (250.97-1315.63) to 380.69 (185.68-915.03), p = 0.004] and normalized to baseline levels after 6-months of L-glutamine supplementation [634.96 (139.57-3103.61), p < 0.001]. For HSP70, levels decreased after 3-months of L-glutamine supplementation [548.86 (31.50-1564.51) to 353.65 (110.58-752.50), p = 0.045] and remained low after 6-months of L-glutamine supplementation [309.30 (118.29-1744.19), p = 0.517]. Patients with high HSP27 levels at baseline showed normalization of several metabolites related to the carbohydrates, nucleotide...Continue Reading

References

Jun 4, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Petra G BoelensNicolaas E P Deutz
Jun 24, 2005·Intensive Care Medicine·Thomas R ZieglerPaul E Wischmeyer
Jan 27, 2006·American Journal of Physiology. Cell Physiology·Angela L MorrisonPaul E Wischmeyer
Aug 1, 2006·Journal of Molecular and Cellular Cardiology·Bianca J J M BrundelHarm H Kampinga
Nov 18, 2006·Circulation Research·Bianca J J M BrundelStanley Nattel
Mar 11, 2008·Cardiovascular Research·Bianca J J M BrundelHarm H Kampinga
Jan 29, 2009·Critical Care : the Official Journal of the Critical Care Forum·Anne Sofie AndreasenBente Klarlund Pedersen
Sep 25, 2009·American Journal of Physiology. Cell Physiology·Christine R HamielPaul E Wischmeyer
Sep 6, 2011·European Heart Journal·Ulrich Förstermann, William C Sessa
Aug 7, 2012·Trends in Cardiovascular Medicine·Femke Hoogstra-BerendsBianca J J M Brundel
Jun 27, 2014·Clinical Epidemiology·Massimo Zoni-BerissoStefano Domenicucci
Jan 7, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Seppo Ylä-Herttuala
Feb 24, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Iolanda JordanElisabeth Esteban
May 8, 2015·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·E A H LantersB J J M Brundel
Jul 23, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jaqueline Santos Moreira LeiteJulio Tirapegui
Aug 11, 2016·Frontiers in Immunology·Zarah BatulanEdward R O'Brien
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Oct 27, 2018·Nutrients·Vinicius CruzatPhilip Newsholme
Jun 21, 2019·CNS Neuroscience & Therapeutics·Long-Long LuoYong-Ting Wang
Feb 23, 2020·Cell Metabolism·Marte MolenaarsRiekelt H Houtkooper

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Citations

Jan 21, 2021·International Journal of Molecular Sciences·Stan W van WijkBianca J J M Brundel
Oct 23, 2020·Cells·Bianca J J M Brundel
Aug 28, 2021·International Journal of Molecular Sciences·Lisa PoolBianca J J M Brundel

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Methods Mentioned

BETA
ELISA

Software Mentioned

R
Bruker TASQ

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