Daily urinary interleukin-11 excretion correlated with proteinuria in IgA nephropathy and lupus nephritis

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Jien-Wen ChienChing-Yuang Lin

Abstract

Interleukin-11 (IL-11) is a multifunctional cytokine with both thrombopoietic and anti-inflammatory effects. In an animal study IL-11 was shown to reduce proteinuria in mice with necrotizing glomerulonephritis. The purpose of this current study is to explore the role of IL-11 in human glomerulonephritis. Subjects of this study were patients with proteinuria (daily urine protein excretion >40 mg/m2 per hour) and underlying pathology of IgA nephropathy (IgAN) (n=20), lupus nephritis (LN) (n=40), and idiopathic nephrotic syndrome (INS) (n=68). Daily urinary IL-11 level was measured by enzyme-linked immunosorbent assay (ELISA). Correlation between urinary IL-11 and urinary protein was determined by Pearson's correlation coefficient. Another five patients with serial data of urinary protein, IL-11 and IL-11 messenger RNA (mRNA) expression in urine sediment are presented. The correlation between urinary IL-11 and daily urinary protein was significant for patients with IgAN (r=0.596, P=0.006) and LN (r=0.630, P<0.001), but not for patients with INS (r=0.030, P=0.812). Serial data revealed the same correlation. Furthermore, the peak of urinary IL-11 mRNA preceded that of urinary IL-11. We conclude that daily urinary IL-11 excretion is ...Continue Reading

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Citations

Oct 25, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael ZappitelliIndra R Gupta
Dec 21, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koji TsugawaHiroshi Tanaka
Sep 17, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kazushi TsurugaHiroshi Tanaka
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May 25, 2010·Acta Paediatrica·Kazushi TsurugaHiroshi Tanaka
Mar 16, 2019·Biomedicines·Aaron L MagnoVance B Matthews
Feb 6, 2020·British Journal of Pharmacology·Benjamin CordenStuart A Cook

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