Daio-Orengedokudo works as a cell-proliferating compound in endothelial cells

Canadian Journal of Physiology and Pharmacology
Ki-Ho ChoHeonyong Park

Abstract

Daio-Orengedokuto is a combination drug that has inhibitory effects on HMG-CoA reductase and pancreatic lipase. Here we investigated whether Daio-Orengedokuto has effects on vascular endothelial cells. To determine its effects on blood vessels, we examined roles of Daio-Orengedokuto in cell migration, cell apoptosis and cell cycle progression over bovine aortic endothelial cells (BAECs). Interestingly, Daio-Orengedokuto was shown to work as an anti-apoptotic agent, a cell cycle progressive agent and a cell-migration inducing agent in BAECs, whereas it was known to act as a tumor suppressor in cancer cells (unpublished data). The inducing effect of Daio-Orengedokuto on cell-cycle progression and cell migration in endothelium suggests that Daio-Orengedokuto may be referred to as a drug, inducing angiogenesis, healing wounds, and (or) remodeling vascular tissue. Then we further investigated which signaling molecules were activated by Daio-Orengedokuto and found that extracellular signal-regulated kinase (ERK) phosphorylation and IkappaB degradation were stimulated by the Daio-Orengedokuto treatment in BAECs. More interestingly, pretreatment with PD compound, an ERK inhibitor, blocked the anti-apoptosis induced by Daio-Orengedokuto...Continue Reading

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Citations

Jan 21, 2014·Complementary Therapies in Clinical Practice·Seong-Uk ParkJongbae J Park
Jun 25, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Woo-Sang JungKi-Ho Cho
Jul 27, 2018·Journal of Evidence-based Integrative Medicine·Woo-Sang JungSeungwon Kwon
Jun 23, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jaeyoung ShinHeonyong Park

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