Dalteparin for deep venous thrombosis: a hospital-in-the-home program.

The Medical Journal of Australia
S B TingB P McGrath

Abstract

To assess the efficacy, safety and cost savings of home treatment of lower-limb deep venous thrombosis (DVT). A hospital-in-the-home treatment program. One hundred patients with acute lower limb DVT (53 proximal, 47 distal), and no contraindication to home treatment, were entered into the program from March 1995 to February 1997. All patients received dalteparin, 200 units/kg subcutaneously, once daily for a minimum of five days, with commencement of oral anticoagulation (warfarin) on Day 2. Patients with proximal DVT had lung ventilation-perfusion scans performed and were admitted to hospital for at least 24 hours. Patients with distal DVT were discharged directly to home treatment. Clinical responses and the results of sequential duplex ultrasonography at one week, one month, three months and six months. There were no major, but six minor, bleeding complications, two of which led to dalteparin being withdrawn. Sixteen patients had lung ventilation-perfusion scans showing a high probability of pulmonary embolism. All were asymptomatic, and follow-up for at least three months showed no symptomatic thromboembolic events. Duplex ultrasonography showed progression of thrombosis in the first week of therapy in 13.2% of distal and 2...Continue Reading

References

May 30, 1991·The New England Journal of Medicine·J Hirsh
Feb 1, 1986·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·B N RaghavendraS Lam
Nov 1, 1995·Journal of Vascular Surgery·M H MeissnerD E Strandness
Dec 15, 1994·The New England Journal of Medicine·E E Weinmann, E W Salzman
Dec 12, 1996·The New England Journal of Medicine·J S Ginsberg

❮ Previous
Next ❯

Citations

Apr 29, 1998·The Medical Journal of Australia·C N Chesterman
Apr 29, 1998·The Medical Journal of Australia·M L Grayson
Jul 1, 2014·Journal of Thrombosis and Haemostasis : JTH·S Takach LapnerC Kearon
Sep 4, 1999·The Medical Journal of Australia·H M Nespolon
Apr 5, 2000·PharmacoEconomics·W E WadeM Perri
Aug 11, 2000·Australian and New Zealand Journal of Public Health·N BoardG A Caplan
Jan 10, 2018·The Cochrane Database of Systematic Reviews·Richard OthienoRachel Forster
Jan 29, 2002·Hospital Medicine·D J Perry
Apr 26, 2003·Anaesthesia and Intensive Care·S A Watts, N M Gibbs
Nov 25, 2003·Journal of Clinical Nursing·Maxine Duke, Annette Street
Jul 5, 2005·Expert Opinion on Investigational Drugs·H T Zhang, A L Harris
Mar 6, 2007·Journal of Thrombosis and Thrombolysis·Thomas M HyersUNKNOWN INNOVATE Investigators
Jul 20, 2007·The Cochrane Database of Systematic Reviews·R OthienoE Okpo
Oct 22, 2010·The American Journal of Medicine·Paul D SteinGary L Willyerd
Jun 23, 2020·International Journal of Nursing Studies·Lucas M A GoossensMaureen P M H Rutten-van Mölken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.