Damage assessment in gastric cancer treatment with adjuvant radiochemotherapy: calculation of the NTCP's from the differential HDV of the organs at risk.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Amadeo WalsIsmael Herruzo

Abstract

To calculate the Normal Tissue Complication Probabilities (NTCP) for the liver, right kidney, left kidney and spinal cord, as well as the global Uncomplicated Tumour Control Probability (UTCP) in gastric cancer patients who underwent a treatment with radiotherapy after radical surgery in our environment. In April 2000, a postoperative chemotherapy (QT-RT) protocol started in the province of Malaga for Gastric Adenocarcinomas with postsurgical stage II or higher (pT3-4 and/or pN+). This clinical protocol served as a base for our NTCP and UTCP retrospective theorical study. A virtual simulation and a 3D planning were made in all cases. The differential HDV, selected for each patient were obtained for the 4 organs at risk (OR). Hystograms reduction was made by the Kutcher and Burman's Effective Volume method. NTCP calculations by Lyman's models. The following variables were calculated: maximal dose for each organ (Dmax), Effective Volume (Veff), TD50 (Veff/Vref); NTCP for each organ of the patient; global UTCP for each patient. Differences between the 2 treatment techniques were analysed (2-field versus 4-field technique). For the NTCP calculations the computer application Albireo 1.0(R) was used. 29 patients to assess with an ave...Continue Reading

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Citations

Jun 25, 2015·Revista da Associação Médica Brasileira·E WeltmanUNKNOWN Brazilian Society for Radiation Oncology
Sep 24, 2016·Annals of the Royal College of Surgeons of England·T TakiK Yanaga
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yasemin Guzle AdasSalih Ergocen
Oct 9, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Tim CardilinJohan Gabrielsson

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