Damage of charge-dependent renal tubular reabsorption causes diabetic microproteinuria.

Diabetes Research and Clinical Practice
K KunikaM Itakura

Abstract

More negatively-charged proteins are harder to pass through the glomerular charge barrier (GCB) and to be reabsorbed by renal tubules. Although the glycation of albumin increases its negative charge compared to non-glycated albumin, the glycation of transferrin does not change its charge. This difference enabled us to examine the charge-dependent renal function in diabetic proteinuria. The percentage of urinary glycated transferrin (serum %G-transferrin) positively correlated with serum fructosamine concentrations and the percentage of serum glycated albumin (serum %G-albumin) in all subjects. Urinary concentrations of transferrin and beta 2-microglobulin strongly correlated in diabetic patients with microproteinuria, while no significant correlation was observed in subjects with diabetic macroproteinuria or non-diabetic proteinuria. Urine/serum (U/S) ratio of %G-albumin in the patients with diabetic proteinuria was significantly lower than that in subjects with non-diabetic proteinuria, while no difference of the U/S ratio of %G-transferrin was observed between any groups. Furthermore, U-%G-transferrin/U-%G-albumin ratio was highest in the diabetic patients with microproteinuria. These results lead to the conclusion that the i...Continue Reading

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Citations

Nov 9, 2007·Medicinski pregled·Vlastimir VlatkovićSpomenka Nogić
May 17, 2007·Srpski arhiv za celokupno lekarstvo·Vlastimir VlatkovićSpomenka Nogić
Mar 14, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Vlastimir VlatkovićRadmila Obrenović
Jul 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tessa J M WijnhovenToin H van Kuppevelt
Jul 15, 2016·Journal of Diabetes Research·Cristina GluhovschiBogdan Timar
Jan 6, 2004·Free Radical Research·Ann van CampenhoutBegoña Manuel-y-Keenoy
Feb 13, 2008·Nature Clinical Practice. Nephrology·Dhruv K SinghKen Farrington
Jun 18, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yanqi MaSongbo Fu

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