PMID: 6985280Jan 1, 1982Paper

Damage of photoreceptor membrane lipids and proteins induced by photosensitized generation of singlet oxygen

Current Eye Research
A A ShvedovaV E Kagan

Abstract

It has been shown that illumination of rod outer segment suspension in the presence of photosensitizers (methylene blue lambda greater than or equal to 620 nm; retinal 370 less than or equal to lambda less than or equal to 390 nm) results in chemical modification of the lipid and protein components of the photo-receptor membranes. This modification can be registered by accumulation of lipid peroxidation (LPO) products as well as oligomerization of rhodopsin and a decrease of rhodopsin thermal stability. These effects are prevented by 'O2-quenchers and free radical scavengers. It has been found that the electric activity (ERG) of isolated frog retina is inhibited due to photosensitized generation of 'O2 which can be overcome by preliminary addition of 'O2-quenchers and free radical scavengers to the incubation medium. The LPO products are accumulated in the retinae of rats exposed to high intensity light in vivo. It is concluded that 'O2 and LPO are involved in light-induced damage of the retina.

References

Jan 1, 1979·Vision Research·A A ShvedovaV E Kagan
May 1, 1972·American Journal of Ophthalmology·M O Ts'oL E Zimmerman
Jan 1, 1980·Vision Research·M A Bloome
Oct 31, 1980·Biochemical and Biophysical Research Communications·N Bennett
Nov 1, 1952·The Japanese Journal of Physiology·E KIMURA
Nov 20, 1958·The Journal of General Physiology·R HUBBARD

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Citations

Sep 3, 2010·The Journal of Clinical Investigation·Przemyslaw SapiehaSylvain Chemtob
Mar 16, 2012·Photochemistry and Photobiology·Kosuke MasutomiYiannis Koutalos
Feb 1, 1997·Pediatric Clinics of North America·P HardyS Chemtob
Apr 27, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Pierre HardySylvain Chemtob
Aug 20, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Chunhe ChenYiannis Koutalos
Sep 1, 1986·Metabolic Brain Disease·G KonatR C Wiggins
Dec 1, 1984·Current Eye Research·E W Harlan, R Crouch
Mar 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H ZhangC D Agardh
Apr 2, 1987·Biochimica Et Biophysica Acta·A C NyeV S Prabhu
Aug 1, 1988·Experimental Eye Research·W F Zimmerman, S Keys

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