Damage to neurons and oligodendrocytes in the hippocampal CA1 sector after transient focal ischemia in rats.

Cellular and Molecular Neurobiology
Hiroto UchidaTsutomu Araki

Abstract

Focal brain lesions such as transient focal cerebral ischemia can lead to neuronal damage in remote areas, including the ipsilateral substantia nigra and hippocampus, as well as in the ischemic core. In this study, we investigated acute changes in the ipsilateral hippocampus from 1 up to 7 days after 90 min of transient focal cerebral ischemia in rats, using anti-NeuN (neuronal nuclei), anti-Cu/Zn-superoxide dismutase (Cu/Zn-SOD), anti-Mn-SOD, anti-neuronal nitric oxide synthase (nNOS), anti-inducible NOS (iNOS), anti-glial fibrillary acidic protein (GFAP), anti-ionized calcium-binding adaptor molecule 1(Iba 1) and anti-2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) antibodies. In our western blot and histochemical analyses, present results show that transient focal cerebral ischemia in rats can cause a severe and acute damage of neurons and oligodendrocytes in the ipsilateral hippocampal CA1 sector. The present findings also demonstrate that the expression of iNOS produced by Iba 1-immunopositive microglia precedes the damage of neurons and oligodendrocytes in the ipsilateral hippocampal CA1 sector after transient focal cerebral ischemia. In contrast, our results suggest that increased reactive oxygen species (ROS) prod...Continue Reading

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Citations

Apr 22, 2014·Neurochemistry International·Viera DanielisovaJozef Burda
Aug 31, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Wook LimYun Tai Kim
Jan 13, 2018·Chinese Journal of Integrative Medicine·Zi-Gang ZhangBing-Chun Yan
May 8, 2019·Neuroscience Bulletin·Chuan QinDai-Shi Tian
Mar 3, 2021·CNS Neuroscience & Therapeutics·Junxuan LyuXiaoyan Jiang
Oct 10, 2020·Free Radical Biology & Medicine·Kalpana Kumari BarhwalSunil Kumar Hota

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