Damaged chromatin does not prevent the exit from metaphase I in fused mouse oocytes

Human Reproduction
J FulkaR M Moor

Abstract

The presence of checkpoint mechanisms which are able to recognize damaged chromatin and thereafter to prevent exit from metaphase I has been investigated in giant mouse oocytes produced by fusion of a normal metaphase I oocyte with an equivalent oocyte with damaged chromatin. The presence of damaged chromatin did not prevent the onset of anaphase I in both sets of chromatin in the fused cells. Interestingly, fused or unfused cells containing only damaged chromatin failed to enter anaphase and persisted instead in a metaphase-like state. These results demonstrate the fragility of checkpoint controls in mammalian female germ cells.

Citations

May 2, 2002·Molecular Reproduction and Development·Lin LiuDavid L Keefe
Oct 15, 2003·Fertility and Sterility·Julie M ClydeHelen M Picton
Jan 1, 1999·Maturitas·U Eichenlaub-Ritter
Oct 26, 2002·Cloning and Stem Cells·J FulkaW Reik
Jun 16, 1999·Current Opinion in Obstetrics & Gynecology·J Tesarik, E Greco
Jun 24, 2006·Fertility and Sterility·M Cristina MagliLuca Gianaroli
Sep 30, 2005·Cytogenetic and Genome Research·N Steuerwald

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