Dam's infection progress and within-herd prevalence as predictors of Mycobacterium avium subsp. paratuberculosis ELISA response in Danish Holstein cattle

Preventive Veterinary Medicine
S S NielsenPolychronis Kostoulas

Abstract

Understanding the primary routes of transmission of Mycobacterium avium subsp. paratuberculosis (MAP) is pivotal to manage the pathogen in cattle herds. MAP is transmitted both vertically and horizontally, and both the dam's stage of infection and the prevalence in the population are therefore potentially important for MAP transmission control. The objective of this study was therefore to assess the dam's infection progress and the within-herd test-prevalence as predictors of MAP infection in Danish dairy cattle. MAP specific antibody ELISA records from 95,025 dam-offspring pairs were combined with test-prevalence estimates from 939 Danish Holstein herds. The odds of testing ELISA-positive given the within-herd test-prevalence and the time-period a dam had had MAP specific antibodies were estimated for the offspring. Both dams and offspring were tested as adults, and parity-group was used to correct for the effect of age. The results showed that both the within-herd test-prevalence and the dam's infection progress were significant predictors, while the dams that had tested positive when giving birth and up to 0.7 years after were more likely to have offspring that would test positive. The odds of testing positive were about 1.5...Continue Reading

References

Jun 16, 2000·Preventive Veterinary Medicine·M B JakobsenS S Nielsen
Oct 12, 2007·The Veterinary Journal·Richard J Whittington, Peter A Windsor
Mar 20, 2009·Preventive Veterinary Medicine·Polychronis KostoulasIan A Gardner
Feb 5, 2010·Preventive Veterinary Medicine·Polychronis KostoulasLeonidas Leontides
Mar 24, 2011·Journal of Dairy Science·S S Nielsen, N Toft
Oct 26, 2011·The Veterinary Clinics of North America. Food Animal Practice·Raymond W Sweeney
Aug 9, 2015·BMC Veterinary Research·Carsten KirkebySøren Saxmose Nielsen

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