Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro

American Journal of Obstetrics and Gynecology
H IkegamiK Matsumoto

Abstract

Based on our recent findings that danazol, an isoxazol derivative of ethinyltestosterone, has a profound growth-inhibitory effect on an established human endometrial adenocarcinoma cell line, the effects of danazol on cancer cells from human endometrial adenocarcinomas obtained by hysterectomy were investigated in the present study. Of the 22 uterine adenocarcinomas, estrogen, progesterone, and androgen receptors were found in 12, 14, and 4 tumors, respectively. Competitive binding studies showed that danazol specifically binds to progesterone and androgen receptors but not to estrogen receptors. Of the five cancer cells from five patients succeeded in primary cell culture, a marked inhibition of cell growth was demonstrated by addition of danazol in two cancer cells having progesterone but not androgen receptors. However, danazol did not affect the growth of the remaining three cancer cells lacking progesterone receptors. These results strongly suggest that danazol has a significant growth-inhibitory effect on human endometrial adenocarcinoma cells, possibly through progesterone receptors in the cells.

References

Dec 1, 1976·Gynecologic Oncology·E I Kohorn
Apr 1, 1982·Acta Endocrinologica·E KokkoR Vihko
Jan 1, 1984·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·S JeppssonG Rannevik
Mar 1, 1983·Endocrinology·E Kokko
Mar 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R Punnonen, A Lukola

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Citations

Feb 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L MarianiG Atlante
Jun 27, 2017·The Breast : Official Journal of the European Society of Mastology·Zhazira IrgebayZulfiya Orynbayeva
Jan 1, 1991·Annals of the New York Academy of Sciences·U MontemagnoF Zullo
Jan 1, 1991·Annals of the New York Academy of Sciences·S PecorelliA Gastaldi
Nov 1, 1993·Steroids·S SuzukiH Nagasawa

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