Danazol mimics antigestagen action in first trimester termination of pregnancy

European Journal of Obstetrics, Gynecology, and Reproductive Biology
S Zalányi

Abstract

Based on steroid receptor binding and biologic activity, danazol was suspected to be an antigestagen. To compare with placebo test in first trimester termination of pregnancy (TOP) as a method for predilatation of the cervix prior to application of misoprostol. 52 patients were randomised into two groups. Thereby, 26 women received 200 mg danazol vaginal suppositories three times during 2 days before administering 200 microg misoprostol and undergoing mechanical dilatation and vacuum aspiration 5h later. The other 26 received placebo suppositories and the same treatment otherwise. The uterine cervix was wider and less dilatation and time was needed for the surgical termination in the group pretreated with danazol. There were six cases of complete abortion within 5h of administering misoprostol in the danazol group; and none in the placebo group. After danazol treatment, 16 women exhibited signs of abortion versus four receiving the inert suppositories. Pretreatment with 200mg danazol suppositories three times starting 36 h before administering misoprostol for cervical dilatation enhances the effect of prostaglandin on cervical dilatation and uterine contractions in a manner similar to antigestagens.

References

Mar 1, 1979·Obstetrical & Gynecological Survey·D A Grimes, W Cates
Dec 1, 1992·British Journal of Obstetrics and Gynaecology·K J Thong, D T Baird
Jun 1, 1988·British Journal of Obstetrics and Gynaecology·I E Messinis, A Templeton
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·T TamayaH Okada
Jul 1, 1995·Contraception·E Diczfalusy

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