Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients

Mediators of Inflammation
Leandro BorgesElaine Hatanaka

Abstract

Evidence suggests that exercise improves neutrophil function. The decreased functional longevity of neutrophils and their increased clearance from infectious sites contribute to the increased susceptibility to infection and severity of infection observed in patients with diabetes. Herein, we investigated the effects of a dance program on neutrophil number, function, and death in type 2 diabetes mellitus (T2DM) patients and healthy volunteers. Ten patients with T2DM and twelve healthy individuals participated in a moderate-intensity dance training program for 4 months. The plasma levels of leptin, free fatty acids (FFAs), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-1β (IL-1β), and interleukin-1 receptor antagonist (IL-1ra); neutrophil counts; extent of DNA fragmentation; cell membrane integrity; and production of TNF-α, interleukin-8 (IL-8), interleukin-6 (IL-6), and IL-1β in neutrophils were measured before and after training. Training reduced plasma levels of TNF-α (1.9-fold in controls and 2.2-fold in patients with T2DM) and CRP (1.4-fold in controls and 3.4-fold in patients with T2DM). IL-1ra levels were higher in the control group (2.2-fold) after training. After training, neutrophil DNA fragment...Continue Reading

References

Jan 7, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·R N JohnsonJ R Baker
Jul 27, 2000·Medicine and Science in Sports and Exercise·A AlbrightL S Verity
Feb 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·W G DUNCOMBE
Nov 15, 2006·Clinical and Experimental Immunology·Elaine HatanakaAna Campa
Aug 1, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T C Alba-LoureiroP Sannomiya
Dec 20, 2012·Journal of Strength and Conditioning Research·Nivaldo R de MouraElaine Hatanaka
Aug 6, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Catrine Tudor-LockeWilliam D Johnson
Apr 5, 2014·Mediators of Inflammation·Leandro da Silva BorgesElaine Hatanaka
Dec 24, 2015·Diabetes Care·American Diabetes Association
Jan 20, 2016·Journal of Diabetes and Its Complications·Caroline Pereira DominguetiAna Paula Fernandes
Feb 22, 2016·Current Diabetes Reports·Rodica Pop-BusuiEva L Feldman
May 18, 2016·Journal of Diabetes Investigation·Juan HuangZhiguang Zhou
Dec 1, 2017·The Journal of Physiological Sciences : JPS·Maria Guadalupe Soares AmorimElaine Hatanaka
Jan 27, 2018·Cell Death & Disease·Caroline Maria Oliveira VolpeJosé Augusto Nogueira-Machado
Mar 31, 2018·Frontiers in Physiology·Maria F Cury-BoaventuraElaine Hatanaka
Apr 10, 2019·Nature Immunology·Vijay A K RathinamFeng Shao

Citations

Apr 25, 2020·International Journal of Molecular Sciences·Antonio CrisafulliClaudia Penna
Dec 16, 2020·International Journal of Sports Medicine·Maria Elizabeth Pereira PassosRenata Gorjão
Apr 1, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Valeria ValenteCarmine Morisco

Methods Mentioned

BETA
ELISA
flow cytometry

Related Concepts

C-reactive protein
Plasma Membrane
Cessation of Life
Diabetes
Diabetes Mellitus, Non-Insulin-Dependent
Nonesterified Fatty Acids
Inflammation
Interleukin-1 beta
Interleukin-6
Neutrophil

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