Dancing Styles of Collective Cell Migration: Image-Based Computational Analysis of JRAB/MICAL-L2

Frontiers in Cell and Developmental Biology
Ayuko SakaneTakuya Sasaki

Abstract

Collective cell migration is observed during morphogenesis, angiogenesis, and wound healing, and this type of cell migration also contributes to efficient metastasis in some kinds of cancers. Because collectively migrating cells are much better organized than a random assemblage of individual cells, there seems to be a kind of order in migrating clusters. Extensive research has identified a large number of molecules involved in collective cell migration, and these factors have been analyzed using dramatic advances in imaging technology. To date, however, it remains unclear how myriad cells are integrated as a single unit. Recently, we observed unbalanced collective cell migrations that can be likened to either precision dancing or awa-odori, Japanese traditional dancing similar to the style at Rio Carnival, caused by the impairment of the conformational change of JRAB/MICAL-L2. This review begins with a brief history of image-based computational analyses on cell migration, explains why quantitative analysis of the stylization of collective cell behavior is difficult, and finally introduces our recent work on JRAB/MICAL-L2 as a successful example of the multidisciplinary approach combining cell biology, live imaging, and computa...Continue Reading

References

Jan 12, 2001·Physiological Reviews·Y TakaiT Matozaki
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·M Zerial, H McBride
Jun 12, 2002·Molecular Biology of the Cell·Anne-Marie MarzescoAhmed Zahraoui
Nov 6, 2004·The Journal of Biological Chemistry·Shinya MorimotoTakuya Sasaki
Jan 6, 2005·Journal of Cell Science·Houchaima Ben-TekayaHans-Peter Hauri
Jan 22, 2005·Current Opinion in Genetics & Development·Erik Sahai
Jun 17, 2005·IEEE Transactions on Medical Imaging·O DebeirC Decaestecker
Sep 6, 2005·IEEE Transactions on Visualization and Computer Graphics·Holger TheiselHans-Peter Seidel
Mar 10, 2006·Molecular Biology of the Cell·Tomoya TeraiTakuya Sasaki
Nov 8, 2008·IEEE Transactions on Visualization and Computer Graphics·Xavier TricocheCarl-Fredrik Westin
Jun 24, 2009·Nature Reviews. Molecular Cell Biology·Peter Friedl, Darren Gilmour
Nov 17, 2009·IEEE Transactions on Visualization and Computer Graphics·Thomas SchultzHans-Peter Seidel
Dec 3, 2009·The Journal of Cell Biology·Peter Friedl, Katarina Wolf
Dec 17, 2009·Molecular and Cellular Biology·Ayuko SakaneTakuya Sasaki
Apr 20, 2010·Trends in Cell Biology·Roberto Mayor, Carlos Carmona-Fontaine
Sep 14, 2010·Current Opinion in Cell Biology·Ryan S GrayAndrew J Ewald
Dec 9, 2010·Genesis : the Journal of Genetics and Development·Khaled Khairy, Philipp J Keller
Jan 21, 2011·Physiological Reviews·Alex H Hutagalung, Peter J Novick
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Thomas E AngeliniDavid A Weitz
Nov 29, 2011·Cell·Peter Friedl, Stephanie Alexander
Sep 5, 2012·Current Opinion in Cell Biology·Eric Theveneau, Roberto Mayor
Dec 18, 2012·Bioinformatics·Fernando AmatPhilipp J Keller
Feb 5, 2013·Nature Cell Biology·Damien RamelGregory Emery
Jun 8, 2013·IEEE Transactions on Visualization and Computer Graphics·Harsh BhatiaPeer-Timo Bremer
Aug 13, 2013·PloS One·Katica BoricKathleen Whitlock
Jan 29, 2014·Current Molecular Medicine·V CastañedaS Härtel
Jul 24, 2014·Small GTPases·Mirjam M Zegers, Peter Friedl
Oct 21, 2015·Trends in Cell Biology·Paola MasuzzoLennart Martens
Nov 4, 2015·IEEE Transactions on Visualization and Computer Graphics·Christopher P KappeHeike Leitte
Sep 1, 2016·Annual Review of Cell and Developmental Biology·Veronika Te BoekhorstPeter Friedl
Sep 2, 2016·Molecular Biology of the Cell·Ayuko SakaneTakuya Sasaki
Aug 31, 2017·Scientific Reports·Mishel GeorgeOtger Campàs
Nov 8, 2017·Developmental Cell·Kazuhiro AokiMichiyuki Matsuda
Nov 9, 2017·Nature Reviews. Molecular Cell Biology·Benoit Ladoux, René-Marc Mège
Dec 23, 2017·Nature Cell Biology·Sjoerd van HelvertPeter Friedl

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technology
PCA

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.