Dandelion flower-like micelles.

Chemical Science
Yongchao YaoShiyong Zhang

Abstract

Dandelion flower-like micelles (DFMs) were prepared by self-assembly of polycaprolactone (PCL) functionalized surface cross-linked micelles (SCMs). Upon reductive stimuli, the SCMs can be released from the DFMs by non-Brownian motion at an average speed of 19.09 μm s-1. Similar to the property of dandelion flowers dispersing their seeds over a long distance, the DFMs demonstrated enhanced multicellular tumor spheroid (MTS) penetration, a useful property in the treatment of many diseases including cancer, infection-of-biofilm diseases and ocular problems.

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Citations

Dec 5, 2020·Advanced Healthcare Materials·Yongchao YaoShiyong Zhang
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Meihui YinHuining Xiao
Sep 28, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Akifumi KawamuraTakashi Miyata

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Methods Mentioned

BETA
dynamic
transmission electron microscopy
fluorescence resonance
FRET
fluorescence microscopy
flow cytometry

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