Dandy-Walker malformation complex: correlation between ultrasonographic diagnosis and postmortem neuropathology

Obstetrics and Gynecology
Joanna J PhillipsR P Kapur

Abstract

This autopsy-based study was designed to evaluate sonographic and neuropathologic findings of fetuses diagnosed prenatally with Dandy-Walker malformation complex. The retrospective study encompassed a series of 44 autopsy cases from 2 tertiary referral centers with a prenatal ultrasound diagnosis of Dandy-Walker malformation complex between 1995 and 2003. Ultrasound and pathology data from the cases and from age-matched controls were reviewed in a blinded manner. An unequivocal diagnosis of Dandy-Walker malformation complex from ultrasonography or pathology archival images required significant hypoplasia or aplasia of the cerebellar vermis. Neuropathologic examination failed to confirm the prenatal diagnosis of Dandy-Walker malformation complex in 59% (26/44, 95% confidence interval [CI] 44-72) of the cases. After standardized reevaluation of high quality archival sonograms and pathology images, concordance remained poor at 55% (6/11 cases, 95% CI 28-79). Sonographic features that favored concordance included marked enlargement of the cisterna magna (> or = 10 mm), complete aplasia of the vermis, and a trapezoid-shaped gap between the cerebellar hemispheres. This latter finding contrasted with a keyhole-shaped gap in fetuses wi...Continue Reading

References

Dec 1, 1992·Radiology·J A EstroffB R Benacerraf
Aug 1, 1989·American Journal of Obstetrics and Gynecology·P D RussM J Johnson
Feb 1, 1988·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·D A NybergB S Mahony
Jan 1, 1987·Pediatric Neuroscience·J A GoldenD A Bruce
Dec 1, 1984·Radiology·B S MahonyW K Hoddick
Jun 22, 1984·JAMA : the Journal of the American Medical Association·P J Benke
Sep 1, 1984·Journal of Neurosurgery·J F HirschE Hoppe-Hirsch
Aug 1, 1994·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·M T KeoganB S Hertzberg
Oct 27, 1997·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B UlmG Bernaschek
Jun 10, 1998·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C V IsaksenS H Torp
Feb 9, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·C C SunJ S Dungan
Oct 8, 1999·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·F A Aletebi, K F Fung
Nov 27, 1999·Obstetrics and Gynecology·D LevineR R Edelman
Mar 31, 2000·Prenatal Diagnosis·N KölbleR Huch
Dec 16, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G PiluB Valeri
Dec 16, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S G CarrollP W Soothill
Dec 18, 2001·Prenatal Diagnosis·J P BernardY Ville
Mar 6, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Y ZalelR Achiron
May 1, 2002·Prenatal Diagnosis·Gianluigi Pilu, John C Hobbins
Jul 25, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·O KleinF Brunelle
Jan 1, 1954·Journal of Neuropathology and Experimental Neurology·C E BENDA
May 18, 2004·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·M WaldM Weninger
Jun 12, 2004·Fetal Diagnosis and Therapy·Recep HasSeher Başaran
Oct 2, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R AchironY Zalel
Nov 27, 2004·Pediatric Radiology·Catherine AdamsbaumCatherine Fallet-Bianco

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Citations

Nov 1, 2006·Early Human Development·Zsanett SzigetiCsaba Papp
Sep 27, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Joseph R Siebert
Jun 7, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rozemarijn SnoekRoel de Heus
Mar 22, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E V BeliaevaA A Molgachev
Apr 14, 2007·American Journal of Medical Genetics. Part a·Martin PootRon Hochstenbach
Oct 2, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C StruksnaesC Vogt
Feb 6, 2009·Prenatal Diagnosis·Gustavo MalingerTally Lerman-Sagie
Feb 6, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Ashley J Robinson
May 15, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F D'AntonioA T Papageorghiou
Oct 31, 2009·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Melissa A Parisi
Nov 23, 2010·Developmental Medicine and Child Neurology·Roobin P Jokhi, Elspeth H Whitby
Nov 4, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eftichia V KontopoulosMary H Allen
Sep 13, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D PaladiniE Fulcheri
Dec 21, 2019·Journal of Clinical Ultrasound : JCU·Sihem DarouichNaima Amraoui
Jul 2, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Camilla StruksnæsChristina Vogt
Jun 3, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ori ShenYaron Zalel
Oct 5, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Emma BertucciReuven Achiron
May 15, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Raj P KapurJoseph R Siebert
Aug 5, 2021·Acta Neuropathologica·Parthiv HaldipurKathleen J Millen

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