Dang-Gui-Bu-Xai-Tang modulated the immunity of tumor bearing mice

Immunopharmacology and Immunotoxicology
Chang-Chi HsiehMing-Tsuen Hsieh

Abstract

Dang-Gui-Bu-Xai-Tang (DGBXT), which includes Radix Angelicae Sinensis and Radix Astragali Membranaceus, is a traditional Chinese medicine used to modulate the lymphocyte activity of cancer patients after chemotherapy and radiotherapy. In the present study, we examined the cytotoxicity of DGBXT on transformed cells and the immunomodulating effects of DGBXT in a tumor-bearing murine model. DGBXT markedly inhibited the growth of the EJ-Ha-ras transformed LZEJ and LZEJ-C2 cells lines. Oral administration of DGBXT for three weeks significantly prevented the tumor development in mice that injected with LZEJ-C2 cells subcutaneously. Moreover, DGBXT effectively increased the population of cytotoxic T lymphocytes (CTLs) and NK cells, and down-regulated activated T helper cells (CD4+/CD25+) in spleen and tumor-draining lymph nodes (TDLN). Furthermore, DGBXT stimulated the production of tumor necrosis factor-alpha in in vitro cultured splenocytes. These results might explain the antitumor effects of DGBXT.

References

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Citations

Jan 10, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Takako MatsudaTadashi Hisamitsu
Sep 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Tai-Guo LiuCheng Yi
Nov 18, 2006·Journal of Zhejiang University. Science. B·Wen-jing RuanJian-guang Zhou
Apr 10, 2014·Journal of Traditional and Complementary Medicine·Thing-Fong TzengI-Min Liu
Jul 29, 2010·Phytotherapy Research : PTR·Feng HuangGanggang Shi
Feb 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ma ChunhuaRuan Jie
May 7, 2020·Frontiers in Pharmacology·Robert D HoffmanJian-Li Gao

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