Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes

Phytotherapy Research : PTR
Duncan H F MakK M Ko

Abstract

The effects of pretreatment with Dang-Gui Buxue Tang (DBT, a decoction of Astragali and Angelica roots) and its component herb extracts on myocardial ischaemia-reperfusion (IR) injury were examined in rats ex vivo. DBT and its component herb extracts could protect against myocardial IR injury in a dose-dependent manner. The more potent cardioprotection afforded by DBT pretreatment than that of a mixture of Astragali and Angelica root extracts was associated with a much higher extraction yield of active ingredients from Angelica root in the herbal decoction. The high level of active ingredients might increase their bioavailability after oral administration. DBT pretreatment could enhance myocardial mitochondrial as well as red blood cell (RBC) glutathione status, thereby increasing their resistance to oxidative stress-induced injury in rats. The measurement of RBC glutathione status may serve as a useful index for the antioxidant effect produced by DBT treatment in human subjects.

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Citations

Dec 3, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xian YangJia-Hong Xu
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Zhihong LinKefeng Ruan
Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qing LiuDaping Fan
Sep 27, 2014·BMC Complementary and Alternative Medicine·Chih-Yang HuangDennis Jine-Yuan Hsieh
Nov 1, 2007·Basic & Clinical Pharmacology & Toxicology·Yan-Fei XinYao-Xian Xuan
Aug 9, 2012·Journal of Ethnopharmacology·Shengpeng WangYitao Wang
Feb 18, 2012·Journal of Ethnopharmacology·Helen SheridanJandirk Sendker
Feb 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ma ChunhuaRuan Jie
Aug 18, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li LiuYong Qing Hua
Jul 22, 2010·Pharmaceutical Biology·Rahila AhmadUma Bhandari
Jun 24, 2017·Okajimas Folia Anatomica Japonica·Tomoko NozakiHiromi Ueda
May 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Chengxu MaYingdong Li
Jun 24, 2017·BMC Complementary and Alternative Medicine·Xiao YuJing-Wei Chen
Nov 5, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ya-Ru BaoGuo-Xing Zhang

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