PMID: 45059Aug 4, 1979

Danger of haemodialysis using acetate dialysate in combination with a large surface area dialyser

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
M Viljoen, C H Gold

Abstract

Large surface area, high mass transfer dialysers have recently come into widespread use, and it has been shown that they promote the loss of large amounts of bicarbonate when acetate is used in the dialysate. The present study was designed to confirm these metabolic consequences and quantitatively to compare two commonly used dialysers in this respect. Simultaneous measurement of arterial and venous blood gases has shown that there is a significant reduction in bicarbonate, carbon dioxide tension, and pH of blood returning to the patient from the dialyser. These changes were greatest with the 2,5-m2 hollow-fibre dialyser, and least with the 1,4-m2 coil dialyser. In the chronic dialysis patient in a steady state, these effects may be inconsequential but, in an acutely ill patient, the combination of a dialysate containing acetate and a high-efficiency dialyser may be extremely hazardous. A return to the use of bicarbonate as the source of base would avoid such hazards and would promote the more physiological correction of the metabolic acidosis of renal failure.

Related Concepts

Metabolic Process, Cellular
Hemodialysis
Dialysis Solutions
Kidney Failure
Carbonic Acid Ions
Renal Insufficiency
Anion Gap
Ion Exchange
Bicarbonate Measurement
Bicarbonates

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

The Journal of the Association of Physicians of India
K C GurudevM K Mani
Journal of the American Society of Nephrology : JASN
C W Oettinger, J C Oliver
Proceedings of the European Dialysis and Transplant Association
P DegouletM Vonlanthen
© 2020 Meta ULC. All rights reserved