Danger signals in regulating the immune response to solid organ transplantation

The Journal of Clinical Investigation
Jamie L Todd, Scott M Palmer

Abstract

Endogenous danger signals, or damage-associated molecular patterns (DAMPs), are generated in response to cell stress and activate innate immunity to provide a pivotal mechanism by which an organism can respond to damaged self. Accumulating experimental and clinical data have established the importance of DAMPs, which signal through innate pattern recognition receptors (PRRs) or DAMP-specific receptors, in regulating the alloresponse to solid organ transplantation (SOT). Moreover, DAMPs may incite distinct downstream cellular responses that could specifically contribute to the development of allograft fibrosis and chronic graft dysfunction. A growing understanding of the role of DAMPs in directing the immune response to transplantation has suggested novel avenues for the treatment or prevention of allograft rejection that complement contemporary immunosuppression and could lead to improved outcomes for solid organ recipients.

References

Aug 10, 1995·The New England Journal of Medicine·P I TerasakiS Takemoto
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Mar 1, 1996·Transplant Immunology·K TriebR Margreiter
Mar 20, 1999·Transplantation Proceedings·M TanakaK Sekiguchi
Mar 23, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K AbeS Kohno
Jan 21, 2001·The Journal of Biological Chemistry·Y OkamuraJ F Strauss
Mar 27, 2001·Transplantation Proceedings·A J CoitoJ W Kupiec-Weglinski
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geoffrey B JohnsonJeffrey L Platt
May 17, 2003·The Journal of Clinical Investigation·Daniel R GoldsteinFadi G Lakkis
May 30, 2003·American Journal of Respiratory and Critical Care Medicine·Scott M PalmerDavid A Schwartz
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bethany M TesarDaniel R Goldstein
Apr 6, 2005·Transplantation Proceedings·B InterewiczM Maksymowicz
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Corinna DoegeBjoern Nashan
Oct 26, 2005·Nature Medicine·Dianhua JiangPaul W Noble
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas B ThornleyDale L Greiner
May 9, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Cecilia Johnsson, Gunnar Tufveson
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G WieczorekV Nickeleit
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kunihiko IzuishiTimothy R Billiar
Sep 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L ChenA Chong
Feb 6, 2007·Transplantation Proceedings·U OttG Wolf
Mar 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y HuangF Gong
Sep 15, 2007·The Journal of Clinical Investigation·Huiling WuSteven J Chadban
Apr 1, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Outi E PäiväniemiUlla-Stina Salminen
Sep 9, 2008·Journal of Biochemistry·Gordon D WuAndrew S Klein
Oct 15, 2008·Transplantation·Irene K KimStefan G Tullius
Feb 6, 2009·The Journal of Biological Chemistry·Jason WebberAled Phillips
Feb 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bernd KrügerBernd Schröppel
Apr 24, 2009·Transplant Immunology·Stephanie SarriJames E Fildes
Jan 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Tomohiro NishiokaKyoko Imanaka-Yoshida
May 12, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Karen L WoodAndrea I Doseff
Jul 2, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Simo O SyrjäläKarl B Lemström
Aug 18, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Lihua DuanMin Fang
Oct 19, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marcus FranzAndre Renner
Jul 1, 2008·Proteomics. Clinical Applications·Edmond O'RiordanMichael S Goligorsky
Jan 21, 2011·Physiological Reviews·Dianhua JiangPaul W Noble
Mar 3, 2011·The FEBS Journal·Aimin WangVincent Hascall
Apr 15, 2011·The New England Journal of Medicine·Marcelo CypelShaf Keshavjee
Jun 16, 2011·Clinical and Experimental Immunology·A M ShieldsV M Corrigall
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Liliana Schaefer
Oct 1, 2011·The Journal of Pathology·Adam J BoothD Keith Bishop

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Citations

Oct 21, 2017·Expert Opinion on Biological Therapy·Massimo Morfini
Apr 6, 2019·Transplantation·Emmanuel Zorn, Sarah B See
Nov 15, 2019·American Journal of Respiratory Cell and Molecular Biology·Stephen Juvet, Tereza Martinu
Oct 28, 2019·American Journal of Respiratory Cell and Molecular Biology·Beñat MallaviaMark R Looney
Jun 26, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chao WeiWeiyun Shi
Jul 10, 2020·The Journal of Clinical Investigation·Tengfang LiHēth R Turnquist
Mar 23, 2018·Bone Marrow Transplantation·Jacob RozmusKirk R Schultz
Feb 26, 2020·International Journal of Molecular Sciences·Monika BednarczykMatthias Bros
Jun 25, 2019·Frontiers in Immunology·Manuel Alfredo PodestàFederica Casiraghi
Feb 15, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Liwen LinTodd V Brennan
Jul 29, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tian YuLucia Kuffova
Dec 2, 2020·European Journal of Dentistry·Alexander Patera NugrahaIgo Syaiful Ihsan
Dec 6, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Palak ShahSean Agbor-Enoh
Jun 21, 2020·Cellular Immunology·Jacqueline H Y SiuGavin J Pettigrew
Mar 2, 2021·American Journal of Respiratory Cell and Molecular Biology·Wenbin YangAnkit Bharat
Mar 1, 2021·The Journal of Thoracic and Cardiovascular Surgery·Jared N GloriaUNKNOWN Duke Ex Vivo Organ Laboratory
May 7, 2020·Journal of Hepatology·Hui HanNatalia Nieto
Dec 29, 2021·Immunological Medicine·Rafael Cardoso Maciel Costa SilvaBruno Ricardo Barreto Pires

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Methods Mentioned

BETA
intragraft
biopsies
pharmacotherapy

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